新医学2017，Vol.48Issue(12)：829-832,4.DOI:10.3969/j.issn.0253-9802.2017.12.002
黄芩苷在心肌纤维化中的作用
The role of baicalin in myocardial fibrosis
摘要
Abstract
In China,plant-derived compounds,which are considered safe for the human body,have been widely used in the medical field.Baicalin,a kind of flavonoids extracted from the rhizomes of Scutellaria baicalensis,possesses significant biological activity.Multiple traditional Chinese medicine formulations containing baicalin are widely used in the treatment of various diseases,and have a high position in clinical medicine.Myocardial fibrosis is the histopathological feature of cardiac remodeling formed in the end-stage of most heart diseases,and it can destroy the cardiac structure,damage the heart function,increase the risk of adverse cardiovascular events such as malignant arrhythmias and sudden cardiac death,thereby severely threatening human health.Myocardial fibrosis occurs due to a variety of factors including inflammation,apoptosis,p38 mitogen-activated protein kinase,matrix metalloproteinases and transforming growth factor-β.In this paper,the biological effects of baicalin on myocardial fibrosis are expounded through elucidating the interaction between baicalin and these pro-fibrosis factors.关键词
黄芩苷/转化生长因子-β/心肌纤维化Key words
Baicalin/Transforming growth factor-β/Myocardial fibrosis引用本文复制引用
门素珍,刘巍..黄芩苷在心肌纤维化中的作用[J].新医学,2017,48(12):829-832,4.基金项目
国家自然科学基金面上项目(81270310) （81270310）
哈尔滨市科技创新人才研究专项资金(杰出青年人才)(2016RAYBJ005) （杰出青年人才）
黑龙江省教育厅海外学人重点项目(1252HQ013) （1252HQ013）
