新医学2017，Vol.48Issue(12)：874-877,4.DOI:10.3969/j.issn.0253-9802.2017.12.011
胸腔热灌注治疗联合静脉化学治疗对晚期非小细胞肺癌合并恶性胸腔积液的临床疗效分析
Clinical efficacy of intrapleural hyperthermic perfusion combined with intravenous chemotherapy in treatment of advanced-stage non-small cell lung cancer complicated with malignant pleural effusion
摘要
Abstract
Objective To evaluate the clinical efficacy of intrapleural hyperthermic perfusion combined with intravenous chemotherapy in the treatment of advanced-stage non-small cell lung cancer complicated with malignant pleural effusion.Methods Clinical data of 70 non-small cell lung cancer patients complicated with malignant pleural effusion were collected.All enrolled patients were divided into the observation (n =35)and control groups (n =35) according to the therapeutic approach.All patients received puncture drainage of the pleural effusion.In the observation group,intrapleural hyperthermic perfusion combined with intravenous chemotherapy was delivered and intravenous chemotherapy alone was performed in the control group.The shortterm clinical efficacy and the incidence of adverse reactions were statistically compared between two groups.Results The short-term clinical efficacy and the overall effective rate in the observation group were significantly higher compared with those in the control group (both P ＜0.01).No statistical significance was identified in terms of the incidence of adverse reactions between two groups (all P ＞ 0.05).After corresponding treatment,the KPS and PG-SGA scores in both groups were significantly improved (both P ＜ 0.05),whereas no statistical significance was observed between two groups (both P ＞ 0.05).Conclusion Intrapleural hyperthermic perfusion combined with intravenous chemotherapy is a more efficacious treatment of non-small cell lung cancer complicated with malignant pleural effusion compared with intravenous chemotherapy alone,which reduces the incidence of adverse reactions and enhances the quality of life of patients.关键词
胸腔热灌注治疗/静脉化学治疗/非小细胞肺癌/恶性胸腔积液Key words
Intrapleural hyperthermic perfusion therapy/Intravenous chemotherapy/Non-small cell lung cancer/Malignant pleural effusion引用本文复制引用
陈永东,陈祖龙,周明,张金野..胸腔热灌注治疗联合静脉化学治疗对晚期非小细胞肺癌合并恶性胸腔积液的临床疗效分析[J].新医学,2017,48(12):874-877,4.基金项目
广东省医学科研基金(A2016214) （A2016214）
