中国医疗设备2017，Vol.32Issue(12)：11-14,4.DOI:10.3969/j.issn.1674-1633.2017.12.003
功能神经导航及术中磁共振对语言区病变语言保护作用研究
Protective Effect of Multimodal Navigation and Intraoperative Magnetic Resonance Imaging on Language Function in Cerebral Lesions Involving Language Area
摘要
Abstract
Objective To evaluate the impact of multimodal navigation and intraoperative magnetic resonance imaging (iMRI) on extent of resection, gross total resection and preservation of language function. Methods A total of 65 patients with cerebral lesions involving arcuate fasciculus (AF) were enrolled. Impact of multimodal navigation and iMRI on surgical strategies, extent of resection, rate of gross total resection (GTR) and language function were analyzed. Results Extent of resection was overestimated in 12 cases (18.5%) by the neurosurgeons, compared with the first iMRI. The first iMRI confirmed total resection of non-glioma lesions. First iMRI demonstrated gross total resection in 21 patients and incomplete resection in 33 cases. Further resection was continued with updated imaging in 25 patients. Additional tumor resection in 25 cases increased extent of resection from 87.3%to 97.4%, resulting in improvement of mean resection degree in glioma cases from 92.1% to 96.8%. Compared with preoperative language function status, 15 cases (23.1%) got new or worsened language dysfunction 2 weeks after surgery. At 6-month follow-up, only 2 patients had a permanent postoperative language deficit. Conclusion Multimodal navigation and iMRI help maximal resection of cerebral lesions while minimum injury to language function, which can improve health related quality of life.关键词
神经导航/术中磁共振/语言/弥散张量成像/弓形束Key words
multimodal navigation/intraoperative magnetic resonance imaging/language/diffusion tensor tractography/arcuate fasciculus分类
医药卫生引用本文复制引用
李昉晔,陈晓雷,侯远征,孙国臣,张家墅,余新光,许百男..功能神经导航及术中磁共振对语言区病变语言保护作用研究[J].中国医疗设备,2017,32(12):11-14,4.基金项目
国家自然科学基金(81771481) （81771481）
解放军总医院科技创新苗圃基金(16KMM14) （16KMM14）
解放军总医院临床科研扶持基金(2017FC-TSYS-2012). （2017FC-TSYS-2012）
