中国医疗设备2017，Vol.32Issue(12)：60-62,82,4.DOI:10.3969/j.issn.1674-1633.2017.12.014
便携式膜法氧气机在模拟高原慢性缺氧环境下对大鼠血液指标的影响
Effects of Portable Oxygen-Enriched Machine on Blood Indices of Rats Under Simulated Chronic Hypoxic Environment
摘要
Abstract
Objective To evaluate the application performance of portable oxygen-enriched machine by studying the effects of portable oxygen-enriched machine on blood indices of rats under simulated chronic hypoxic environment. Methods Chronic hypoxic environment was simulated by small hypobaric chamber and oxygen-enriched rooms were established by portable oxygen-enriched machines and individually ventilated cages. 36 male Sprague-Dawley rats were randomly divided into 3 groups: normal control group (NC group), high altitude hypoxia group (HH group) and high altitude oxygen enrichment group (HO group). Rats of HH group and HO group were fed in the small hypobaric chamber for 4 weeks (22 h every day) and the rats of HO group also were fed in oxygen-enriched rooms for 8 hours every day. Rats of NC group were fed outside of the chamber at the same time. The blood indices of rats were measured after 4 weeks. Results No statistical differences were found in the level of WBC of 3 groups (P>0.05). But compared with NC group and HO group, the levels of RBC, Hb, HCT, MCV and MCH of HH group were significantly increased (P<0.05 or P<0.01), and no statistical difference was found between NC group and HO group (P>0.05). Conclusion Portable oxygen-enriched machine can enhance adaptive ability of rats by reducing level of RBC and improving functional reserve of blood system under simulated chronic hypoxic environment.关键词
高原慢性缺氧/低压舱/富氧/血液指标/氧气机Key words
chronic hypobaric hypoxia/hypobaric chamber/oxygen enrichment/blood indices/oxygen-enriched machine分类
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董旭,雷涛,罗二平..便携式膜法氧气机在模拟高原慢性缺氧环境下对大鼠血液指标的影响[J].中国医疗设备,2017,32(12):60-62,82,4.基金项目
国家科技支撑计划项目(2012BAI20B00) （2012BAI20B00）
十二五全军后勤科研项目(CWS12J098). （CWS12J098）
