针刺研究2017，Vol.42Issue(6)：547-551,5.DOI:10.13702/j.1000-0607.2017.06.016
针刺干预慢性疼痛突触可塑性变化:“疼痛记忆”的机制探讨
Advances in Acupuncture Mechanism Research on the Changes of Synaptic Plasticity: "Pain Memory" for Chronic Pain
摘要
Abstract
Previous studies have shown that there are many common structures between the neural network of pain and memory,and the main structure in the pain network is also part of the memory network.Chronic pain is characterized by recurrent attacks and is associated with persistent ectopic impulse,which causes changes in synaptic structure and function based on nerve activity.These changes may induce long-term potentiation of synaptic transmission,and ultimately lead to changes in the central nervous system to produce "pain memory".Acupuncture is an effective method in treating chronic pain.It has been proven that acupuncture can affect the spinal cord dorsal horn,hippocampus,cingulate gyms and other related areas.The possible mechanisms of action include opioid-induced analgesia,activation of glial cells,and the expression of brain derived neurotrophic factor (BDNF).In this study,we systematically review the brain structures,stage of "pain memory" and the mechanisms of acupuncture on synaptic plasticity in chronic pain.关键词
慢性疼痛/针刺/可塑性/记忆/综述Key words
Chronic pain/Acupuncture/Plasticity/Memory/Review分类
医药卫生引用本文复制引用
杨一玲,黄键澎,蒋丽,刘健华..针刺干预慢性疼痛突触可塑性变化:“疼痛记忆”的机制探讨[J].针刺研究,2017,42(6):547-551,5.基金项目
国家自然科学基金(No.81673888) （No.81673888）
国家自然科学青年基金(No.81403461) （No.81403461）
