摘要
Abstract
Aim The application of neuregulin-1 (NRG-1) and captopril alone or in combination,the mechanism of heart failure and the improvement of cardiac function in rats with heart failure were analyzed.Methods A total of 100 SD rats were randomly divided into NRG-1 group,captopril group,combination group,pseudo-operation group and control group.In addition to the pseudo-operation group,the other four groups were made into rat heart failure model on the basis of puncture operation.Rats in the NRG-1 group and the captopril group were treated with NRG-1 and captopril,respectively,and rats in the combination group were given NRG-1 combined with captopril,and the effect of different regimen on the inhibition of cardiomyocyte apoptosis and the improvement of cardiac function were compared.Results Compared with the pseudo-operation group,the cardiac function index decreased,the plasma BNP concentration increased,the hemodynamic index changed,the hypertrophy index increased,the apoptosis index of the cardiomyocytes increased,the difference was statistically significant (P＜0.05).Compared with the control group,the indexes of cardiac function,plasma BNP,hemodynamics,cardiac hypertrophy and cardiomyocyte apoptosis index were significantly improved in NRG-1 group,captopril group and combination group after 8 weeks of treatment,the difference was statistically significant (P＜0.05).And NRG-1 group was superior to captopril group (P＜0.05) in plasma BNP concentration and myocardial cell apoptosis index (P＜0.05),and the effect of the above indexes was better than that of captopril and NRG-1 alone group (P＜0.05).Conclusion NRG-1 and captopril in the treatment of heart failure can effectively inhibit myocardial cell apoptosis,improve heart function,if the two drugs in combination,can further enhance the efficacy.关键词
神经调节蛋白1/卡托普利/心功能/细胞凋亡/大鼠Key words
Neuregulin-1/Captopril/Cardiac function/Apoptosis/Rats分类
医药卫生
