中国动脉硬化杂志2017，Vol.25Issue(11)：1120-1125,6.
心肌梗死患者血清低密度脂蛋白亚组分及与临床生物化学指标的相关性
The correlation between serum low density lipoprotein subfractions and clinical biochemical indicators in patients with myocardial infarction
摘要
Abstract
Aim To investigate the distribution characteristics of plasma low density lipoprotein (LDL) subfractions in patients with myocardial infarction and to analyze the correlation between the subfractions and serum clinical biochemical indicators in patients with acute myocardial infarction (AMI) and old myocardial infarction (OMI).Methods The fresh serum of 14 patients with acute myocardial infarction (AMI),24 patients with old myocardial infarction (OMI) and 19 healthy subjects at the Second Mfiliated Hospital of Dalian Medical University from June to December in 2015 were collected and screened.Plasma LDL subfractions composition and content were determined by Lipoprint subclass analysis system.Results Serum LDL average particle diameter,the content and percentage of I-LDL were significantly decreased (P＜0.01),and the content and percentage of S-LDL were significantly increased in acute myocardial infarction and old myocardial infarction (P＜0.01).From acute myocardial infarction to old myocardial infarction,serum S-LDL,especially correlation of LDLsc,LDL6C,LDL7c and serum TC,LDLC,ApoB,CK-MB,cTnT had undergone significant changes.Conclusion Compared with LDLC concentration increase,the decrease of LDL particle size and the increase of S-LDL content and percentage were very important for the accurate detection and diagnosis of patients with clinical myocardial infarction.The correlation between serum LDLsC,LDL6C,LDL7C and clinical biochemical indicators have great diagnostic value for the diagnosis of acute myocardial infarction and the differential diagnosis of acute myocardial infarction.关键词
急性心肌梗死/陈旧性心肌梗死/低密度脂蛋白亚组分/总胆固醇/载脂蛋白B/肌酸激酶同工酶/心肌肌钙蛋白TKey words
Acute myocardial infarction/Old myocardial infarction/Low density lipoprotein subfractions/Total cholesterol/Apolipoprotein B/Creatine kinase isoenzyme/Cardiac troponin T分类
医药卫生引用本文复制引用
米春芳,刘庆平..心肌梗死患者血清低密度脂蛋白亚组分及与临床生物化学指标的相关性[J].中国动脉硬化杂志,2017,25(11):1120-1125,6.基金项目
国家自然科学基金项目资助(81673494) （81673494）
