中国动脉硬化杂志2017，Vol.25Issue(11)：1126-1131,6.
血浆氧化三甲胺水平与急性心肌梗死患者并发症的关系
Relationship between plasma trimethylamine-N-oxide levels and complication risk in patients with acute myocardial infarction
摘要
Abstract
Aim To investigate the relationship between plasma trimethylamine N-oxide (TMAO) levels and complication risk in patients with acute myocardial infarction (AMI).Methods 200 consecutive AMI patients admitted into Cardiology Department of Affiliated Hospital of Putian University from January 2014 to December 2015 were enrolled.Patients were categorized into complication group (n=158) and non-complication group (n =42) according to the presence or absence of new-onset symptomatic heart failure,arrhythrnia or cardiac shock.Patients were divided into quartiles based on TMAO levels (≤2.43 μmol/L,2.43-3.66 μmol/L,3.67-6.18 μmol/L and ≥6.18 μmol/L,respectively),and odds ratio (OR) of incident complication was calculated by using logistic regression.Correlation of TMAO with cardiac troponin Ⅰ (cTnI),N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) were analysed by Spearman rank correlation analysis.Results TMAO levels in complication group were significantly higher than those in non-complication group (6.4±1.8 μmol/L vs 4.2±1.3 μmol/L,P＜0.05).TMAO levels of AMI patients were positively associated with complication risk.After adjustment for age,diabetes,estimated glomerular filtration rate,left ventricular end-diastolic dimension,left ventricular ejection fraction,and plasma NT-proBNP,cTnI and hs-CRP levels,patients in the highest quartile of TMAO entailed 6.01 times greater risk for complication than those in the lowest quartile of TMAO (95％ confidence interval:2.03 ～ 17.73,P＜0.05).Correlation of TMAO levels with cTnI was the strongest,followed by NTproBNP and hs-CRP (rs =0.64,0.62 and 0.38 respectively,all P＜0.05).Conclusion Higher TMAO is associated with increased risk of AMI complication and elevated plasma cTnI and NT-proBNP levels.关键词
氧化三甲胺/急性心肌梗死/N末端脑钠肽前体/心肌肌钙蛋白ⅠKey words
Trimethylamine N-oxide/Acute myocardial infarction/N-terminal pro-brain natriuretic peptide/Cardiac troponin Ⅰ分类
医药卫生引用本文复制引用
许开祖,林丽明,吴莹,许锦鸿,吴梅芳..血浆氧化三甲胺水平与急性心肌梗死患者并发症的关系[J].中国动脉硬化杂志,2017,25(11):1126-1131,6.基金项目
福建省自然科学基金项目(2017J01344) （2017J01344）
