中国动脉硬化杂志2017，Vol.25Issue(11)：1138-1142,1168,6.
血清miR-663、miR-126和miR-370对冠心病患者支架内再狭窄的预测价值
Predictive value of serum miR-663, miR-126 and miR-370 for in-stent restenosis in patients with coronary heart disease
摘要
Abstract
Aim To investigate the serum expressions of miR-663,miR-126 and miR-370 of microRNA (miR-NA) after stent implantation in patients with coronary heart disease,and to analyze the predictive value of the above 3 types of miRNA in in-stent restenosis (ISR).Methods The study included 175 patients with coronary heart disease,who underwent coronary stent implantation and followed up coronary angiography,and the patients were divided into ISR group (n =66) and non-ISR group (n =109) according to the results of angiography.The clinical data were analyzed and compared in the two groups.The serum samples of all patients were collected and the expression levels of serum miR-663,miR-126 and miR-370 were detected by real-time quantitative PCR.The values of the above 3 types of miRNA predicting ISR were analyzed by statistical methods.Results A total of 66 cases of ISR occurred in 175 patients with coronary heart disease after stent implantation.Smoking rate was higher in ISR group (P＜0.05).The levels of blood glucose,low density lipoprotein cholesterol and high-sensitivity C-reactive protein (hs-CRP) in ISR group were higher than those in nonISR group (P＜0.01).The expressions of serum miR-663 and miR-126 in ISR group were lower than those in non-ISR group,but the expression of miR-370 was higher than that in non-ISR group (all P＜0.01).Logistic regression analysis showed that the expression levels of miR-663 and miR-126 were related to ISR,and smoking and hs-CRP were independent risk factors of ISR.The results of receiver operating characteristic curve showed that the area under curve (AUC) of miR-663,miR-126 and miR-370 predicting ISR were 0.772,0.720 and 0.650,respectively,while the AUC of miR-663 com-bined with miR-126 predicting ISR was 0.909,which was superior to the prediction efficiency of single miRNA.Conclusion The expressions of miR-663 and miR-126 were decreased and the expression of miR-370 is increased in patiems with ISR after coronary stent implantation.Serum miR-663,miR-126 and miR-370 can be used to predict the occurrence of ISR,and miR-663 combined with miR-126 can significantly improve the efficacy of ISR prediction.关键词
冠心病/支架内再狭窄/微小RNAKey words
Coronary heart disease/In-stent restenosis/MicroRNA分类
医药卫生引用本文复制引用
王芳,李蓓,刘成伟,吴明祥,苏唏..血清miR-663、miR-126和miR-370对冠心病患者支架内再狭窄的预测价值[J].中国动脉硬化杂志,2017,25(11):1138-1142,1168,6.基金项目
武汉市卫计委课题(WX14C78) （WX14C78）
