中国动脉硬化杂志2017，Vol.25Issue(11)：1149-1151,3.
早期糖尿病肾病血清NGAL与致动脉硬化指数的关系
The relationship between serum neutrophil gelatinase associated lipocalin and atherogenic index of plasma in diabetic nephropathy
摘要
Abstract
Aim To investigate the clinical value of neutrophil gelatinase-associated lipocalin (NGAL) for the early diabetic nephropathy (DN),and further explore the relationship of NGAL and atherogenic index of plasma.Methods 120 cases of patients with diabetes mellitus were divided into 2 groups according to the urinary albumin creatinine ratio(UA/Cr).In addition,there is a control group including 60 cases of healthy subjects.NGAL,hypersensitive c-reactive protein (hs-CRP) and lipid related indicators of all cases were measured and the atherogenic index of plasma (AIP) was calculated.The changes of NGAL,hs-CRP,AIP were compared and analyzed.All cases were divided into three groups according to the three digits of AIP.The changes of NGAL and hs-CRP were analyzed.Simple linear correlation and multiple linear regression analysis were performed for all variables.Results The level of NGAL,AIP and hs-CRP in normal albuminuria group and DN group was significantly increased compared with control group(P＜0.001).The level of NGAL,AIP and hs-CRP in DN group was significantly increased compared with normal albuminuria group(P＜0.001).Serum NGAL level increased obviously as the rise of the AIP three digits.AIP were positively correlated with hs-CRP and NGAL(r=0.296,0.313,P＜0.05).Independent influencing factors for AIP were NGAL and hs-CRP.Conclusion NGAL is an index for early DN.NGAL is an acute phase reaction protein which is involved in the development of atherosclerosis in diabetic nephropathy.关键词
糖尿病肾病/中性粒细胞明胶酶相关载脂蛋白/致动脉硬化指数Key words
Nephropathy/Neutrophil gelatinase-associated lipocalin/Atherogenic index of plasma分类
医药卫生引用本文复制引用
杨朝菊,赵培,张明明,申艳梅,高哲,帖彦清..早期糖尿病肾病血清NGAL与致动脉硬化指数的关系[J].中国动脉硬化杂志,2017,25(11):1149-1151,3.基金项目
河北省医学科学研究重点课题(20160080) （20160080）
