中国动脉硬化杂志2017，Vol.25Issue(11)：1169-1173,5.
血管钙化中成骨样细胞来源及其转化的研究进展
Research progress of the origin of osteoblast-like cells and phenotypic transition in vascular calcification
摘要
Abstract
Vascular calcification is a multi-factor mediated,reversible and active regulation process.It involves a large number of cytokines and signaling pathways.The essence of vascular calcification is an ostooblastic phenotypic shift in some vascular cell types,resulting in vascular wall thickening,lumen stenosis and vascular remodeling.Recent studies have showed that several kinds of vascular cells including vascular smooth muscle cells,calcifying vascular cells,pericytes and mesenchymal stem cells in vascular walls have the potential to differentiate into osteoblast-like phenotype.Therefore,it is important to study the origin of the osteoblast-like cells and the modulation of phenotypic transition related to the vascular calcification.关键词
血管钙化/血管平滑肌细胞/钙化血管细胞/周细胞/间充质干细胞Key words
Vascular calcification/Vascular smooth muscle cells/Calcifying vascular cells/Pericytes/Mesenchymal stem cells分类
医药卫生引用本文复制引用
严泽振..血管钙化中成骨样细胞来源及其转化的研究进展[J].中国动脉硬化杂志,2017,25(11):1169-1173,5.基金项目
国家自然科学基金项目(81370399和91539106) （81370399和91539106）
