中国临床药理学与治疗学2017，Vol.22Issue(9)：998-1001,4.
地塞米松对急性胰腺炎小鼠胰腺组织中NF-κB及survivin表达的影响
Effects of dexamethasone on the expression of NF-κB and survivin in acute pancreatitis
摘要
Abstract
AIM:To explore the effect of dexamethasone on the expression of NF-κB and survivin in pancreas in acute pancreatitis (AP).METHODS:AP animal model were established using caerulein and were divided into the saline group (control group),the AP group and dexamethasone group.The ELISA method was used to detect TNF-α in serum in each group.Real-time Q-PCR and Western blot were used to detect NF-κB,survivin,TNF-α mRNA and protein expression in pancreas in each group.RESULTS:The results of ELISA test showed that dexamethasone could significantly reduce the content of TNF-α in serum compared with the AP group.The results of qPCR and Western blot showed that dexamethasone could significantly reduce the expression of survivin,NF-κB,TNF-α mRNA and protein in pancreas compared with the AP group.CONCLUSION:Through inhibiting the NF-κB activation,dexamethasone could inhibit the expression and anti-apoptotic effect of survivin,promote apoptosis,reduce necrosis of pancreatic acinar cells,and inhibit the synthesis and release of TNF关键词
地塞米松/急性胰腺炎/凋亡Key words
dexamethasone/acute pancreatitis/apoptosis分类
医药卫生引用本文复制引用
杨飞云,朱秀英,张建新,杨亚勤..地塞米松对急性胰腺炎小鼠胰腺组织中NF-κB及survivin表达的影响[J].中国临床药理学与治疗学,2017,22(9):998-1001,4.基金项目
河南省组织再生重点实验室开放课题项目(KFKT16003) （KFKT16003）
