中国临床药理学与治疗学2017，Vol.22Issue(9)：1008-1011,4.
NR2A拮抗剂对神经病理性痛大鼠海马突触长时程增强的影响
Effect of antagonist of NR2A-containing N-methyl-D-aspartate receptors on synaptic long-term potentiation in hippocampus in rats with neuropathic pain
摘要
Abstract
AIM:To investigate the effect of antagonist of NR2A-containing N-methyl-D-aspartate (NMDA) receptors on synaptic long-term potentiation (LTP) in the hippocampus in rats with neuropathic pain.METHODS:Twenty-four adult male Wistar rats were randomly divided into four groups (n =6 each):sham operating group (group S),S + NVP-AAM077 group (group SN),neuropathic pain group (group NP) and NP + NVP-AAM077 group (group NPN).Neuropathic pain was produced by ligation of the right LA and L5 spinal nerve.The excitatory post-synaptic potential (EPSP) in hippocampal CA1 region was measured at 3 day after the last measurement of pain threshold.The changes in EPSP and LTP of the CA1 stratum radiatum of the rat hippocampus were observed using stereotaxic technology and extracellular recording respectively.RESULTS:The pain threshold was significantly lower in group NP and NPN,and the amplitude of EPSP was significantly higher in group NP and NPN than in group S and SN (P ＜ 0.05),but there was no significant difference in the amplitude of EPSP between group NP and NPN.CONCLUSION:The facilitation of LTP induction by neuropathic pain in the CA1 area of the hippocampus may be little relationship with the activation of NR2Acontaining NMDA receptors.关键词
神经痛/长时程增强/N-甲基-D-门冬氨酸受体/海马Key words
neuralgia/long-term potentiation/N-methyl-D-aspartate receptors/hippocampus分类
医药卫生引用本文复制引用
魏辉明,麻伟青,李文锋,王慧明..NR2A拮抗剂对神经病理性痛大鼠海马突触长时程增强的影响[J].中国临床药理学与治疗学,2017,22(9):1008-1011,4.基金项目
成都军区“十二五”医学科研项目(B14013) （B14013）
