中国临床药理学与治疗学2017，Vol.22Issue(9)：1029-1034,6.
长期应用核苷(酸)类药物治疗对慢乙肝患者肾功能的影响
Effects of nucleos(t)ide analogues on renal function in patients with chronic hepatitis B
摘要
Abstract
AIM:To summarize the effects of nucleoside (acid) drugs on renal function in accepting antiviral therapy chronic hepatitis B patients.METHODS:Clinical data of 176 cases of chronic hepatitis B patients treated with nucleoside (acid)antiviral therapy (28 cases in ADV + LAM treatment group,20 cases in ADV + ETV group,21 cases in LAM group,26 cases in ADV group,81 cases in group ETV) were recorded,estimated glomerular filtration rate (eGFR) was calculated.The KruskalWallis test or Mann-Whitney test or chi square difference test were used for comparative analysis of differences.RESULTS:The eGFR of the patients in ADV + LAM treatment group,ADV + ETV group,LAM group,ADV group and ETV group were (78.9 ± 13.8),(80.2 ±15.8),(78.8 ±12.9),(74.6 ± 14.6),(79.5 ±13.1) mL · min-1 · 1.73 m2,respectively,P ＞ 0.05;the number of cases with eGFRless than 80 mL · min-1 · 1.73 m2 were 14 (50％),12(60％),10(47.6％),20(69.2％),47 (58.0％),respectively,P ＞ 0.05.Serum phosphorus levels were (0.95 ±0.14),(0.92 ±0.11),(1.02±0.13),(0.92 ±0.16),(0.97 ±0.14) mmol/L,respectively,P ＞ 0.05;the number of cases with a decreased serum phosphorus level were 15 (53.6％),13(65％),6(28.6％),13(50％),39 (48.1％),respectively;Furthermore,there were statistically significant differences between LAM group and ADV + ETV group (x2 =5.466 9,P =0.019 4).CONCLUSION:Long-term antiviral therapy of nucleoside (acid) drugs may affect renal function,in which the effect of ADV is the most obvious,ETV is the second,and LAM is the mildest.The monitoring of eGFR and serum phosphorus level is more sensitive to reveal the damage of kidney.关键词
肾小球滤过率估算值(eGFR)/肾损害/拉米夫定/阿德福韦酯/恩替卡韦Key words
estimated glomerular filtration rate/renal damage/lamivudine/adefovir/entecavir分类
医药卫生引用本文复制引用
霍娜,陆海英,王贵强,黄明杰,吴赤红,蔺小红..长期应用核苷(酸)类药物治疗对慢乙肝患者肾功能的影响[J].中国临床药理学与治疗学,2017,22(9):1029-1034,6.基金项目
国家十二五科技重大专项资助项目(2012ZX10002003) （2012ZX10002003）
