中国临床药理学与治疗学2017，Vol.22Issue(9)：1040-1044,5.
石杉碱甲联合艾司西酞普兰对抑郁症临床疗效及认知功能的影响
Effects of huperzine A combined with escitalopram on clinical efficacy and cognitive function in depression patients
摘要
Abstract
AIM:To evaluate the effect of huperzine A combined with escitalopram on clinical efficacy and cognitive function in depression patients.METHODS:Sixty patients with depression were randomly divided into study group which accepted treatment of huperzine A combined with escitalopram and control group that were given escitalopram only (n =30).All patients in both groups accepted treatment for 8 weeks.The 17-item Hamilton Depression Rating Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA) were assessed as indicators of efficacy;Wisconsin Card Sorting Test (WCST) and Wechsler Memory Scale-Revised of China (WMS-RC) were used for assessment of cognitive function,Treatment Emergent Symptom Scale (TESS) was used to assess the adverse reactions before treatment and 8 weeks after treatment.RESULTS:(1) The total efficacy rate (90.0％) and recovery rate (50.0％) in study group was higher than that in control group (86.7％,46.7％),but the difference was not statistically significant (P ＞ 0.05).The HAMD-17 and HAMA scores in both groups after treatment were significantly lower than that before treatment (P ＜ 0.05),however,the HAMD-17 and HAMA scores between the two groups were similar (P ＞ 0.05).(2) For study group,total trials,preservative errors and random errors of WCST after treatment were significantly lower than those before treatment (P ＜ 0.05) while the total trials after treatment in control group were significantly lower than that before treatment (P ＜ 0.05).The WMS-RC score of long-term,short-term and immediate memory,and memory quotient in two groups were significantly higher than that before treatment in both groups (P ＜ 0.05).After treatment,the random errors of WCST in study group were significantly lower than those in control group.WMS-RC score of long-term memory,short-term memory and memory quotient in study group were significantly higher than that of control group (P ＜ 0.05).(3)No significant difference of adverse reactions were found between two groups (P ＞ 0.05).CONCLUSION:A combination of huperzine A and escitalopram in the treatment of depression has high efficacy and safety similar to escitalopram monotherapy.It also can significantly improve cognitive function which is superior to monotherapy.关键词
石杉碱甲/艾司西酞普兰/抑郁症/临床疗效/认知功能Key words
huperzine A/escitalopram/depression/clinical efficacy/cognitive function分类
医药卫生引用本文复制引用
莫亚莉,夏泳,刘义,陶云海,金曼..石杉碱甲联合艾司西酞普兰对抑郁症临床疗效及认知功能的影响[J].中国临床药理学与治疗学,2017,22(9):1040-1044,5.基金项目
浙江省医药卫生科技计划项目(2010KYA166) （2010KYA166）
