中国临床药理学与治疗学2017，Vol.22Issue(9)：1056-1061,6.
膈下逐瘀汤对瘀血内结型肝癌术后血凝状态与生存质量的影响
Effect of gexiazhuyu decoction on blood coagulable status and life quality of patients with liver cancer
摘要
Abstract
AIM:To analyze the effect of gexiazhuyu decoction on blood coagulable status and life quality of patients with liver cancer,so as to provide evidence for its clinical application.METHODS:105 patients with liver cancer were divided into two groups:the control group (n =52) and the observation group (n =53).All the patients were given surgery,while the patients of the observation group were given gexiazhuyu decoction at the same time.A follow-up of three to five years was completed,and the recurrence rate,survival rate and life quality score of patients were record.Peripheral blood was extracted to detect liver function,hemorheology,vascular endothelial growth factor (VEGF) and intercellular adhesive molecular-1 (ICAM-1).RESULTS:There was no significant difference in postoperative survival curve and survival rate between groups (P ＞ 0.05),while the recurrence rate of the observation group in five years after treatment was lower than that of the control group,the QOL-LC score and self assessment score of the observation group were both higher than those of the control group,and the difference had statistical significance (P ＜ 0.05).There was no significant difference in liver function indexes and blood clotting indexes between groups before treatment (P ＞ 0.05).After treatment,the aspartate amino transferase (AST),alanine aminotransferase (ALT),whole blood high shear viscosity,low shear rates,red cell assembling index,plasma fibrinogen (Fb),VEGF and ICAM-1 of patients were decreased,and the levels of the observation group were lower;the plasma prothrombin time of patients was increased,and the levels of the observation group was higher;all the difference between groups had statistical significance (P ＜ 0.05).CONCLUSION:Gexiazhuyu decoction can remit the blood coagulable states,which is benefit to prevent relapse and improve life quality.关键词
膈下逐瘀汤/中医证型/原发性肝癌/生存质量/血凝状态Key words
gexiazhuyu decoction/TCM syndrome types/primary hepatic carcinoma/life quality/blood coagulable status分类
医药卫生引用本文复制引用
何扬彪,袁春樱,史国军..膈下逐瘀汤对瘀血内结型肝癌术后血凝状态与生存质量的影响[J].中国临床药理学与治疗学,2017,22(9):1056-1061,6.基金项目
宁波市自然科学基金(2016A610199) （2016A610199）
