中国全科医学2017，Vol.20Issue(29)：3590-3595,6.DOI:10.3969/j.issn.1007-9572.2017.01.y01
糖尿病肾病患者心血管疾病患病率及其影响因素分析
Incidence of Cardiac Vascular Disease and Its Risk Factors of Patients with Diabetic Kidney Disease
摘要
Abstract
Objective To investigate the prevalence of cardiac vascular disease and its influencing factors of patients with diabetic kidney disease.Methods A total of 256 patients with diabetic kidney disease who had not received renal replacement therapy in Y.angpu Hospital,Tongji University from January 2014 to October 2015 were selected.Detection of patients with cardiovascular disease was collected.The patients were divided into group combined with cardiac vascular disease (n =159) and group combined without cardiovascular disease (n =97) according to whether they were combined with cardiac vascular disease or not.The general information and laboratory test results including gender,age,body mass,height,history of hypertension,smoking history,hemoglobin,albumin,fasting blood glucose,glycosylated hemoglobin (HbA1c),serum creatinine,serum uric acid,total cholesterol,triglyceride,low density lipoprotein cholesterin,high density lipoprotein cholesterol,lipoprotein (a),calcium,phosphorus,parathyroid hormone,C-reactive protein,brain natriuretic peptide,24 -hour urinary protein quantitation,homocysteine,and serum β2-microglobulin levels of patients were collected.Multivariate Logistic regression analysis was used to analyze the influencing factors of diabetic kidney disease patients combined with cardiac vascular disease.Results Among the 256 patients with diabetic kidney disease,159 (62.11％) were detected with cardiac vascular disease,and the detection rates of coronary artery disease (CAD),left ventricular hypertrophy (LVH),congestive heart failure (CHF),cerebral vascular accident (CVA),and large atherosclerosis (LA) were 21.09％ (54/256),8.20％ (21/256),8.59％ (22/256),23.44％ (60/256),and 49.22％ (126/256) respectively.The detection rates of cardiac vascular disease in patients with chronic kidney disease (CKD) from the first stage to the fifth were 48.94％ (46/94),59.18％ (29/49),69.70％ (46/66),74.07％ (20/27),and 80.00％ (16/20) respectively.There was significant differences in the detection rate of cardiac vascular disease among patients in different stages of CKD (x2 =12.920,P =0.012).There were significant differences in the gender,age,body mass index (BMI),history of hypertension,rate of smoking,HbA1c,serum creatinine,serum uric acid,total cholesterol,low density lipoprotein cholesterin,lipoprotein (a),parathyroid hormone,homocysteine,and serum β2-microglobulin levels of patients between the two groups (P ＜ 0.05).Multivariate Logistic regression analysis showed that age,serum uric acid,lipoprotein (a),homocysteine,and serum β2-microglobulin levels were independent influence factors of diabetic kidney disease patients combined with cardiac vascular disease (P ＜ 0.05).Conclusion The prevalence of cardiac vascular disease is high among the patients with diabetic kidney disease.The age of patients,and the levels of serum uric acid,lipoprotein (a),homocysteine and serum β2-microglobulin have a significant impact on the incidence of cardiac vascular disease in patients with diabetic kidney disease.关键词
糖尿病肾病/心血管疾病/影响因素分析Key words
Diabetic nephropathies/Cardiovascular diseases/Root cause analysis分类
医药卫生引用本文复制引用
蒋茜,周蓉,刘迎,沈杰,王雅楠,冯雪芳,徐雅虹..糖尿病肾病患者心血管疾病患病率及其影响因素分析[J].中国全科医学,2017,20(29):3590-3595,6.基金项目
上海市卫计委资助项目(20144Y0224) （20144Y0224）
