中国全科医学2017，Vol.20Issue(29)：3596-3600,5.DOI:10.3969/j.issn.1007-9572.2017.29.004
原发性高血压病患者交感神经与迷走神经张力对静息心率的影响研究
Effect of Sympathetic and Vagal Tone on Resting Heart Rate among Essential Hypertensive Patients
摘要
Abstract
Objective To investigate the effects of sympathetic and vagal tone changes on resting heart rate (RHR) in patients with essential hypertension.Methods 404 cases of essential hypertension outpatients and hospitalized patients were selected as the subjects from Wuhan No.1 Hospital in 2013.Recorded the standard 12-lead ECG,calculated the RHR using the average RR interval.The patients were divided into RHR-L group (＜60 times/min),RHR-M group (60-＜75 times/min) and RHR-H group (≥75 times/min) according to RHR.Followed by 24 h dynamic electrocardiographic recording,the value of very low frequency band (VLF),low frequency band (LF),high frequency band (HF) and heart rate deceleration force (DC) were calculated using off-line application of dynamic ECG recording and analysis system.Results The VLF,LF,HF,DC,LF/HF of each group were compared,and the differences were statistically significant (P ＜ 0.05).Among them,VLF,LF and HF in RHR-M group were lower than those in RHR-L group.VLF,LF,HF,and DC in RHR-H group were lower than those in RHR-L group and RHR-M group.LF/HF in RHR-H group was higher than RHR-L group and RHR-M group (P ＜ 0.05).TheRHR was negatively correlated with VLF [r=-0.436,95％CI (-0.501,-0.369)],LF [r=-0.290,95％CI (-0.378,-0.205)],HF [r =-0.394,95％CI (-0.468,-0.315)],DC [r =-0.219,95％CI (-0.310,-0.123)] (P＜0.001),and it was positively correlated with LF/HF [r=0.248,95％CI (0.158,0.332)](P ＜0.001).Multivariate linear regression analysis showed that VLF,HF and LF/HF were the influencing factors of RHR in patients with essential hypertensive (P ＜0.05).Conclusion RHR in essential hypertension patients with RHR of 60-＜ 75 times/min are mainly affected by vagal disturbances,while RHR in patients with RHR ≥75 times/min are mainly affected by sympathetic nervous system disorders.关键词
高血压/心率/交感神经系统/迷走神经Key words
Hypertension/Heart rate/Sympathetic nervous system/Vagus nerve分类
医药卫生引用本文复制引用
卢佳佳,宋旷蓉,张硕,邓宇英,赵良桥,黄汉钦,冷永群,叶静,涂婉华..原发性高血压病患者交感神经与迷走神经张力对静息心率的影响研究[J].中国全科医学,2017,20(29):3596-3600,5.基金项目
2015年度武汉市卫计委基金资助项目(WX15B19) （WX15B19）
