中国全科医学2017，Vol.20Issue(29)：3612-3616,5.DOI:10.3969/j.issn.1007-9572.2017.00.039
替吉奥联合奥沙利铂与卡培他滨联合奥沙利铂方案治疗结直肠癌的疗效比较研究
Clinical Efficacy of Postoperative Chemotherapy of SOX versus XELOX in Treating Colorectal Cancer
摘要
Abstract
Objective To compare the clinical efficacy and side effects of postoperative chemotherapy of S-1 combined with oxaliplatin (SOX) with those of capecitabine combined with oxaliplatin (XELOX) in the treatment of colorectal cancer.Methods A total of 92 patients with colorectal cancer treated in the General Hospital of PLA from 2008 to 2013 were selected and divided into the treatment group (50 cases) receiving postoperative 8 cycles of SOX chemotherapy and control group (42 cases) receiving postoperative 8 cycles of XELOX chemotherapy by drawing lot.The follow-up was carried out from starting chemotherapy to December 31st,2016 with death as the end event by regular telephone or correspondence.The occurrence and severity of side effects (myelosuppression,digestive tract reactions,toxicity in heart,liver and kidney,peripheral neuritis,hyperpigmentation) during chemotherapy were recorded.Results During the follow-up period,the recurrence or metastasis rate in the treatment group was similar to that in the control group [30.0％ (15/50) vs.31.0％ (13/42)] (x2 =2.513,P =0.816).The median survival time in the treatment group and the control group was 24.2 and 25.6 months respectively,and there was no significant difference between the two groups in the survival curve (x2 =1.005,P =0.601).There were no significant differences in the incidence of digestive tract reactions,toxicity in heart,liver and kidney,peripheral neuritis and pigmentation between the two groups (P ＞ 0.05).No statistically significant differences in the severity were found between the groups in the severity of bone marrow suppression,digestive tract reactions,toxicity in heart,liver and kidney,peripheral neuritis,and pigmentation (P ＞ 0.05).Conclusion For colorectal cancer patients,SOX chemotherapy can achieve similar effects as the XELOX chemotherapy does,without increasing or aggravating the incidence and severity of toxic and side effects,so it can be used as an alternative first-line chemotherapy for colorectal cancer.关键词
结直肠肿瘤/替吉奥/卡培他滨/抗肿瘤联合化疗方案/药物毒性Key words
Colorectal neoplasms/S-1/Capecitabine/Antineoplastic combined chemotherapy protocols/Drug toxicity分类
医药卫生引用本文复制引用
左富义,于波,聂玉辉..替吉奥联合奥沙利铂与卡培他滨联合奥沙利铂方案治疗结直肠癌的疗效比较研究[J].中国全科医学,2017,20(29):3612-3616,5.基金项目
吴阶平医学基金会专项医学基金资助项目(A0223) （A0223）
