中国全科医学2017，Vol.20Issue(29)：3675-3678,4.DOI:10.3969/j.issn.1007-9572.2017.00.033
趋化因子及其受体在疼痛过程中的机制和作用
Mechanism of Action of Chemokines and Their Receptors in the Pathogenesis of Pain
摘要
Abstract
Chemotaxis is a common response of non-excitable cells stimulated by chemokine.The chemokine receptor of neurons often transducts cascade via activating the heterotrimeric G protein downstream signals and further triggers molecular signal transduction pathway.Chemokines and their receptors play an important role in the occurrence and maintenance of pain.By analyzing the relationship between chemokines and nerve systems,the relationship between chemokines/chemokine receptors and pain,we demonstrated the mechanism of action of chemokines and their receptors in the pathogenesis of pain,suggesting that chemokines and their receptors are potential targets for the development of novel drugs and options for pain management.关键词
疼痛/趋化因子类/受体,趋化因子Key words
Pain/Chemotactic factors/Receptors, chemokine分类
医药卫生引用本文复制引用
李鸿雁,李彤,倪家骧..趋化因子及其受体在疼痛过程中的机制和作用[J].中国全科医学,2017,20(29):3675-3678,4.基金项目
国家自然科学基金资助项目(81502553,81672467,81470165) （81502553,81672467,81470165）
北京市医院管理局临床医学发展专项经费资助项目扬帆计划(ZYLX201507) （ZYLX201507）
首都特色临床研究(Z141107002514065) （Z141107002514065）
兰州市2015年人才创新创业项目(2015-RC-49) （2015-RC-49）
