中国全科医学2017，Vol.20Issue(29)：3679-3682,4.DOI:10.3969/j.issn.1007-9572.2017.06.y26
细胞周期阻滞在急性肾损伤向慢性肾脏病转变中的作用机制研究进展
Research Progress of Mechanism of Cell Cycle Arrest in Chronic Renal Disease after Acute Renal Injury
摘要
Abstract
Acute renal injury (AKI) is one of the most common severe acute diseases.Some patients with AKI may be likely to develop chronic kidney disease (CKD).However,the specific mechanism of CKD after AKI is not clear,which is associated with many factors,such as glomerular sclerosis after compensatory hyperplasia,renal interstitial inflammation and fibrosis,endothelial dysfunction,peritubular capillary rarefaction,oxidative stress and tubular epithelial cell abnormal repair.In recent years,it has been found that tubular epithelial cells abnormal repair after AKI plays a crucial role in developing CKD,and cell cycle arrest of tubular epithelial cells is one of the important mechanisms of epithelial cell abnormal repair.In this review,we summarized the recent advances in how cell cycle arrest links AKI to CKD.关键词
急性肾损伤/慢性肾脏病/细胞周期/综述Key words
Acute kidney injury/Chronic kidney disease/Cell cycle/Review分类
医药卫生引用本文复制引用
高召,陈星华,丁国华..细胞周期阻滞在急性肾损伤向慢性肾脏病转变中的作用机制研究进展[J].中国全科医学,2017,20(29):3679-3682,4.基金项目
国家自然科学基金资助项目(81500516,81570617) （81500516,81570617）
