中国全科医学2017，Vol.20Issue(30)：3731-3735,5.DOI:10.3969/j.issn.1007-9572.2017.00.052
血清尿酸水平对无神经症状颈动脉粥样硬化患者长期预后的影响研究
Long-term Prognosis in Patients with Neurologically Asymptomatic Carotid Atherosclerosis Influenced by Serum Uric Acid Level
摘要
Abstract
Objective To investigate the impact of serum uric acid (SUA) level on long-term prognosis in patients with neurologically asymptomatic carotid atherosclerosis (NACA).Methods The clinical data of 656 patients with NACA who received inpatient treatment in Cangzhou Central Hospital from December 2012 to December 2015 were collected.They were divided into 4 groups based on the interquartile range of serum uric acid level,＞ 75％ group (n =161),51％-75％ group (n =167),25％-50％ group (n =163),＜ 25％ group (n =165).The baseline information of patients was retrospectively analyzed,including gender,age,BMI,complication (hypertension,diabetes,hyperlipemia),smoking,biochemical markers (level of SUA and Hcy),primary endpoint event (all-cause mortality),ssecordary endpoint event (cardiovascular and cerebrovascular morbidity).The deadline was December 31st,2015.Results Gender distribution,prevalence of hypertension,hyperlipemia and smoking,levels of SUA and Hcy differed significantly among the 4 groups (P ＜ 0.05).The all -cause mortality and cardiovascular and cerebrovascular mortality in the 4 groups varied obviously (P ＜ 0.05).Spearman rank correlation analysis indicated that there was a positive correlation between SUA level and all-cause mortality (rs =0.183,P ＜ 0.001);SUA level presented a positive correlation with the cardiovascular and cerebrovascular mortality (rs =0.099,P =0.002).Up to end point,there were 170 deaths from all causes and 109 deaths due to cardiovascular and cerebrovasculardiseases in total.The survival curves of deaths from all causes in the 4 groups were significantly different (x2 =36.100,P ＜ 0.001).The survival curve of deaths due to cardiovascular and cerebrovascular diseases varied substantially by group (x2 =16.898,P =0.001).The analysis with Cox proportional hazard regression models manifested that SUA level was an independent associated factor for deaths from all causes [RR =1.023,95％ CI (1.018,1.028)] and for deaths due to cardiovascular andr cerebrovascular diseases [RR =1.011,95％ CI (1.008,1.014)] in neurologically asymptomatic carotid atherosclerotic patients (P ＜ 0.05).Conclusion SUA level is closely related to all-cause mortality and cardiovascular and cerebrovascular mortality in patients with neurologically asymptomatic carotid atherosclerosis.Increased SUA level indicates poor prognosis of the patients.关键词
颈动脉粥样硬化/颈动脉/尿酸/预后Key words
Atherosclerosis/Carotid arteries/Uric acid/Prognosis分类
医药卫生引用本文复制引用
杨国涛,赵红英,董爱勤..血清尿酸水平对无神经症状颈动脉粥样硬化患者长期预后的影响研究[J].中国全科医学,2017,20(30):3731-3735,5.基金项目
沧州市科技计划项目(151302138) （151302138）
