摘要
Abstract
Objective To investigate the therapeutic time of erythropoietin (EPO) in anemia of prematurity and the effect on anemia of premature infants with different gestational ages.Methods From March 2014 to February 2016,90 cases of premature infants with anemia admitted to Department of Neonatology,Baoding Maternal and Child Health Hospital were selected as study objects.The patients were divided into control group,late treatment group and early treatment group using the lottery method,30 cases in each group.The early treatment group and the late treatment group were given EPO 750 U · kg-1 · w-1 2 weeks and 3 weeks after birth,respectively.And oral iron was given 1 week after the application of EPO till 5 weeks after birth.The control group received regular treatment and was given oral iron 2 weeks after birth till 5 weeks after birth.Hb,hematocrit (HCT),reticulocyte count (Ret),ferritin (SF),folic acid and vitamin B12 levels of each group were measured before and after treatment.The number of patients accepted blood transfusion during treatment in each group were recorded.Results After treatment,levels of Hb,HCT and Ret in late treatment group were higher than those in control group,and levels of Hb,HCT and Ret in early treatment group were higher than those in control group and late treatment group (P ＜ 0.05).There were no statistically significant differences in the folic acid and vitamin B12 difference before and after treatment between early and late treatment group (P ＞ 0.05),while the SF difference before and after treatment in early treatment group were higher than those in late treatment group (P ＜ 0.05).In early treatment group,there were no statistically significant differences in the levels of folic acid and vitamin B12 between big and small gestational age infants (P ＞ 0.05),while the levels of Hb,HCT,Ret,SF in infants with big gestational age were higher than those in infants with small gestational age (P ＜ 0.05).The blood transfusion rate was 63.3％ (19/30),43.3c％ (13/30) and 36.7％ (11/30) during treatment in the control group,late treatment group and early treatment group,respectively.And there were no statistically significant differences in the blood transfusion rate among each group (P =0.099).There was no statistically significant difference in the blood transfusion rate between small (6/15) and big (5/15) gestational age infants in the early treatment group (P ＞ 0.05).Conclusion Early application of EPO 2 weeks after birth can alleviate the degree of anemia in premature infauts,and the treatment effect on big gestational age infants is better than that on small gestational age infants,but blood transfusion can not be completely avoided.关键词
贫血/婴儿,早产/红细胞生成素/血红蛋白/输血Key words
Anemia/Infant, premature/Erythropoietin/Hemoglobin/Blood transfusion分类
医药卫生
