中国全科医学2017，Vol.20Issue(33)：4115-4120,6.DOI:10.3969/j.issn.1007-9572.2017.00.093
戒烟对烟草依赖支气管哮喘患者肺功能和生活质量的影响及伐尼克兰的辅助戒烟作用
Effect of Smoking Cessation with the Aid of Varenicline on the Values of Pulmonary Function Parameters and Asthma-related Life Quality in Bronchial Asthma Patients with Nicotine Dependence
摘要
Abstract
Objective To determine whether the values of pulmonary function parameters and asthma-related life quality can be improved after smoking cessation with the aid of varenicline in bronchial asthma patients with nicotine dependence.Methods A total of 44 previously smoked patients with bronchial asthma who were treated in the Third Affiliated Hospital,Sun Yat-sen University from August 2014 to April 2016 and met the inclusion criteria were recruited.According to the smoking status after 3-month intervention,the patients were divided into complete smoking cessation group (n =17),partial smoking cessation group (n =14) and continued smoking group (n =13).The status of control of asthma was assessed by the doctor after intervention,and by patients themselves by completing the Asthma Control Test (ACT) before and after intervention,values of pulmonary function parameters [FEV1％ pred,FVC％ pred,FEV1/FVC,domiciliary morning/evening peak expiratory flow (PEFam/pm)] before and after intervention,asthma-related life quality assessed by mini AQLQ before and after intervention,and rate of varenicline use were compared among the three groups.Results Statistically significant difference was observed among the three groups after intervention in the control of asthma assessed by doctors (P ＜ 0.05).Although no significant differences were noted in patient self-rated ACT scores among the three groups before intervention (P ＞ 0.05),quitters showed a significant improvement than partial quitters and continued smokers after treatment (P ＜ 0.05).No significant differences were observed in the baseline lung function estimations (FEV1％ pred,FVC％ pred,FEV1/FVC,PEFam and PEFpm) among the three groups (P ＞ 0.05),however,after treatment,only the value of FEV1/FVC remained stable in all groups throughout the study period (P ＞ 0.05),the quitters and partial quitters showed significant improvement in the values of other four parameters (P＜ 0.05);quitters showed higher values of FEV1 ％ pred and PEFpm than continued smokers (P ＜ 0.05),and continued smokers demonstrated lower values of FVC％ pred and PEFam than partial quitters and complete quitters (P ＜ 0.05).Although mini AQLQ scores did not differ significantly among the three groups before treatment (P ＞ 0.05),quitters demonstrated a remarkable improvement than continued smokers after treatment (P ＜ 0.05).A significant difference in the rate of varenicline use was observed after intervention among the three groups (P ＜ 0.05).Conclusion Varenicline could be utilized with a high probability of success for tobacco cessation in smokers with asthma.Asthmatic patients who quit or decreased smoking showed greater improvement in airway obstruction,symptom score,and asthma-related quality of life than those who continued smoking,suggesting that abstaining from smoking is therapeutically beneficial in the management of asthma.关键词
哮喘/戒烟/伐尼克兰/呼吸功能试验/生活质量Key words
Asthma/Smoking cessation/Varenicline/Respiratory function tests/Quality of life分类
医药卫生引用本文复制引用
李洪涛,张天托,邹小玲,王艳红,李文娟..戒烟对烟草依赖支气管哮喘患者肺功能和生活质量的影响及伐尼克兰的辅助戒烟作用[J].中国全科医学,2017,20(33):4115-4120,6.基金项目
广东省科技计划项目(2016A020215220) （2016A020215220）
国家自然科学基金资助项目(81470220) （81470220）
