中国全科医学2017，Vol.20Issue(34)：4270-4274,5.DOI:10.3969/j.issn.1007-9572.2017.34.011
血清硒水平和尿碘水平对甲状腺癌患病的影响研究
Correlation of Serum Selenium and Urinary Iodine Levels with Thyroid Cancer
摘要
Abstract
Objective To investigate the correlation of serum selenium and urinary iodine levels with thyroid cancer. Methods The enrolled participants were all from the Second Affiliated Hospital of Xinjiang Medical University, including 153 cases of thyroid cancer and 154 cases of benign thyroid nodules who received treatment in Department of Vascular and Thyroid Surgery and 327 healthy controls with normal thyroid who underwent physical examination between March and December 2014. Comparisons were made between the groups in terms of sex distribution,age,levels of total thyroid function markers 〔total triiodothyronine (TT 3 ),total thyroxine (TT 4 ),thyroid stimulating hormone(TSH)〕,thyroglobulin antibody (TGAb),thyroid peroxidase antibody (TPOAb),serum selenium (Se),and urinary iodine (UI). The correlation of sex, age,serum Se and UI levels with the prevalence of thyroid cancer was investigated by stepwise multiple regression models. Results Significant differences were observed in sex distribution,age,levels of serum TT 3 ,TT 4 ,TSH,TGAb,TPOAb and Se as well as UI between the thyroid cancer,benign thyroid nodule and control groups (P < 0. 05). The average serum Se levels in healthy controls were higher than those of the benign thyroid nodule group (P < 0. 05). The benign thyroid nodule group had higher average serum Se levels than the thyroid cancer group (P < 0. 05). Significantly lower average UI levels were noted in the thyroid cancer group rather than the other two groups (P < 0. 05). However,there was no significant difference in the average UI levels between the control and benign thyroid nodule groups (P < 0. 05). Stepwise multiple Logistic regression analysis revealed that sex,Se and UI levels were associated factors for thyroid cancer. Conclusion Female,decreased serum Se and increased UI levels might be the associated risk factors for thyroid cancer.关键词
甲状腺肿瘤/硒/碘/影响因素分析Key words
Thyroid neoplasms/Selenium/Iodine/Root cause analysis分类
医药卫生引用本文复制引用
马欣,张丽,杨雯雯,张润晓..血清硒水平和尿碘水平对甲状腺癌患病的影响研究[J].中国全科医学,2017,20(34):4270-4274,5.基金项目
新疆维吾尔自治区自然科学基金资助项目(2013211A057)——乌鲁木齐地区碘和硒营养状态与甲状腺癌的相关性研究 （2013211A057）
