中国全科医学2017，Vol.20Issue(34)：4322-4325,4330,5.DOI:10.3969/j.issn.1007-9572.2017.34.021
参麦注射液联合血液灌流对脓毒性休克患者血流动力学及组织灌注的影响
Effect of Shenmai Injection with Hemoperfusion on Hemodynamics and Tissue Perfusion in Septic Shock
摘要
Abstract
Objective To investigate the effect of shenmai injection with hemoperfusion on hemodynamics and tissue perfusion in septic shock. Methods We enrolled 60 patients with septic shock treated in the ICU,Shaoxing People′s Hospital from January 2015 to August 2016 and randomly divided them into 3 groups with 20 cases in each:group A,group B and group C. All the groups received the conventional therapy. In addition,group B received shenmai injection,and group C received shenmai injection with hemoperfusion. Values of hemodynamic parameters 〔cardiac index (CI),systemic vascular resistance index (SVRI),extravascular lung water index (EVLWI)〕,Acute Physiology and Chronic Health EvaluationⅡ (APACHEⅡ)score,values of laboratory parameters 〔blood lactate (Lac),procalcitonin (PCT),C - reactive protein (CRP),brain natriuretic peptide (BNP)〕were measured before treatment and after seven days of treatment. Results Before treatment,the values of CI,SVRI,EVLWI and APACHEⅡ score did not differ significantly between the groups (P > 0. 05),while after treatment,compared with groups B and C,group A had lower values of CI and SVRI,but higher value of EVLWI and APACHEⅡ score (P < 0. 05);group C had higher values of CI and SVRI,but lower value of EVLWI and APACHE Ⅱ score compared with group B (P < 0. 05). Before treatment,all the groups showed similar values of Lac,PCT,CRP and BNP (P > 0. 05), but after treatment,the values of Lac,PCT,CRP and BNP in group A were found to be the highest (P < 0. 05);and those in group C were the lowest (P < 0. 05). No adverse reactions associated with the pharmacologic therapy or hemoperfusion occurred in all groups during treatment. Conclusion The conventional therapy combined with shenmai injection and hemoperfusion can effectively improving the outcome of septic shock by raising myocardial contractility,stabilizing hemodynamics,and increasing tissue perfusion.关键词
休克,脓毒性/参麦注射液/血液灌流/血流动力学/组织灌注Key words
Shock/septic/Shenmai injection/Hemoperfusion/Hemodynamics/Tissue perfusion分类
医药卫生引用本文复制引用
陆地,俞国峰,吕铁,应利君..参麦注射液联合血液灌流对脓毒性休克患者血流动力学及组织灌注的影响[J].中国全科医学,2017,20(34):4322-4325,4330,5.基金项目
浙江省医学会临床科研基金项目(2015ZYC-A80) （2015ZYC-A80）
