中国全科医学2017，Vol.20Issue(35)：4362-4366,5.DOI:10.3969/j.issn.1007-9572.2017.35.003
高渗氯化钠羟乙基40淀粉注射液对急性颅脑损伤患者细胞因子及神经功能预后的影响研究
Effect of HSH40 on the Expressions of Cytokines and Prognosis of Patients with Acute Traumatic Brain Injury
摘要
Abstract
Objective To investigate the effects of hypertonic saline hydroxyethyl starch 40 (HSH40)on the expressions of cytokines and nerve functions in patients with acute traumatic brain injury. Methods We enrolled 80 cases of acute traumatic brain injury from the First Affiliated Hospital of Gannan Medical University,including 19 mild traumatic brain injury cases,45 moderate injury cases,and 16 severe injury cases. They were equally randomized into Ringer′s solution (LR) group receiving 7-day Ringer′s solution resuscitation and HSH40 group receiving 7-day HSH40 resuscitation. Blood samples were obtained for determination of serum levels of S100B protein,neuron specific enolase (NSE),myelin basic protein (MBP) at the following time points:at administration,1 day,3 days and 7 days after administration. The neurological prognosis was measured at 6 months. Results Among patients with mild and severe traumatic brain injury,compared with those receiving Ringer′s solution resuscitation,those receiving HSH40 resuscitation had lower serum levels of S100B protein and MBP at 1 d,3 d,7 d after administration and lower serum NSE level at 7 d after administration (P < 0. 05). Among those with moderate traumatic brain injury,compared with those receiving Ringer′s solution resuscitation,those receiving HSH40 resuscitation had much lower serum levels of S100B protein and NSE at 7 d after treatment,and much lower serum levels of MBP at 1 d,3 d,7 d after treatment (P < 0. 05). HSH40 group showed better nerve function improvement than LR group at 6 months after treatment(χ2 = 15. 320,P = 0. 003). Conclusion HSH40 can improve the neurological prognosis in patients with acute traumatic brain injury,which may be related with the reduction of the expressions of S100B protein,NSE and MBP.关键词
颅脑损伤/盐水,高渗/S100B/神经元特异性烯醇化酶/髓磷脂碱性蛋白质类Key words
Craniocerebral trauma/Saline solution,hypertonic/S100B/Neuron specific enolase/Myelin basic proteins分类
医药卫生引用本文复制引用
肖华平,程其许,杨小敏,占丽芳..高渗氯化钠羟乙基40淀粉注射液对急性颅脑损伤患者细胞因子及神经功能预后的影响研究[J].中国全科医学,2017,20(35):4362-4366,5.基金项目
江西省科技厅支撑计划(20151BBG70138) （20151BBG70138）
