中国全科医学2017，Vol.20Issue(35)：4372-4377,6.DOI:10.3969/j.issn.1007-9572.2017.05.y08
胰岛素抵抗与2型糖尿病患者脑功能的相关性研究
Relationship between Insulin Resistance and Brain Function in Patients with Type 2 Diabetes Mellitus
葛飞 1程千鹏 1周玉玲 1王雪 1陈曦 1吕肖锋1
作者信息
- 1. 100700 北京市,陆军总医院内分泌科
- 折叠
摘要
Abstract
Objective To investigate the relationship between spontaneous brain activity changes and HOMA-IR in patients with type 2 diabetes mellitus (T2DM). Methods From August 2015 to September 2016,31 T2DM patients treated in Department of Endocrinology,Army General Hospital were selected as T2DM group. At the same time,28 non-T2DM physical examination cases were selected as control group. Body height,body mass and blood pressure were measured,and body mass index (BMI)was calculated. The levels of fasting insulin (FINS),fasting blood glucose (FPG)and glycosylated hemoglobin (HbA 1c )were measured and the HOMA-IR was calculated. 3. 0 T magnetic resonance scanner was used to monitor and collect the data of spontaneous brain activity changes,and the low frequency oscillation amplitude (ALFF)was used to process the data. Pearson correlation analysis was conducted to investigate the correlation between HOMA-IR and ALFF values in the corresponding brain regions. Results There were no significant differences in gender,age,BMI,systolic blood pressure and diastolic blood pressure between the two groups (P > 0. 05). HbA 1c in T2DM group was higher than that in control group (P < 0. 05). The ALFF values in T2DM group were smaller than those in the control group,including left posterior cingulate gyrus,cerebellum, left middle temporal gyrus,right temporal superior temporal gyrus,left triangle,inferior frontal gyrus,left frontal gyrus,left superior temporal gyrus,and left inferior parietal lobule. The ALFF values in T2DM group were higher than those in the control group,including the left parahippocampal gyrus and the right superior frontal gyrus. Pearson correlation analysis showed that HOMA-IR was negatively correlated with ALFF value in cerebellum and right middle temporal gyrus (r =-0. 362,P = 0. 047;r=-0. 383,P = 0. 038). Conclusion Insulin resistance has an effect on brain function in T2DM and may be associated with depression.关键词
糖尿病,2型/胰岛素抵抗/脑功能Key words
Diabetes mellitus,type 2/Insulin resistance/Brain function分类
医药卫生引用本文复制引用
葛飞,程千鹏,周玉玲,王雪,陈曦,吕肖锋..胰岛素抵抗与2型糖尿病患者脑功能的相关性研究[J].中国全科医学,2017,20(35):4372-4377,6.
