中国动物传染病学报2017，Vol.25Issue(6)：32-36,5.
甲流重组犬流感病毒的小鼠致病性研究
PATHOGENICITY OF REASSORTANT CANINE INFLUENZA VIRUS WITH PANDEMIC/2009 IN MICE
摘要
Abstract
In the present study, we assessed the pathogenicity of novel emerging reassortant CIVs carrying pandemic/2009 segments in the mouse model. Mice were infected intranasally with 106 TCID50/mL of 9 H1N1 and 1 H3N2 reassortant CIVs. Results showed that body weights of all mice decreased. Especially, mice infected with A/Canine/Guangxi/LZ56/2015 (H1N1) lost more weights at 4 dpi and 77.78% of mice survived. Besides, these reassortant viruses replicated in turbinates and lungs. The virus titers of reached to 107.3 TCID50/mL in turbanates and 105.3 TCID50/mL in lungs. The pathological lesions were observed, characterized by necrosis of bronchial epithelials, thickness of alveolar septas and interstitial walls and diffuse infiltration of mononuclear cells. Taken together, our results showed that these reassortant CIVs with pandemic/2009 infected BALB/c mice and even caused death.关键词
甲型流感/重组/犬流感病毒/致病性/小白鼠Key words
Pandemic/2009/Canine influenza virus/reassortant/pathogenicity/mice分类
农业科技引用本文复制引用
赵卫锋,王凌霄,韦祖樟,欧阳康,孙文博,黄伟坚,陈樱,何平,周华波,丁仰保,陈泉江,刘琳,李瑞凯,邹媛婧,廖卓韵..甲流重组犬流感病毒的小鼠致病性研究[J].中国动物传染病学报,2017,25(6):32-36,5.基金项目
广西自然科学基金回国项目(2015GXNSFCA139002) （2015GXNSFCA139002）
广西自然科学基金青年基金项目(2016GXNSFBA380219) （2016GXNSFBA380219）
广西大学博士启动项目(XBZ160123) （XBZ160123）
山东省博士基金(BS2013SW022) （BS2013SW022）
