中国循证儿科杂志2017，Vol.12Issue(5)：328-332,5.DOI:10.3969/j.issn.1673-5501.2017.05.002
妊娠期恶性肿瘤孕产妇和新生儿结局的前瞻性队列研究
Maternal and pediatric outcome after maternal cancer diagnosed during pregnancy: A cohort study
段娟 1陈龙 1范悦玲 2蒙萌 3李婕 4史源1
作者信息
- 1. 第三军医大学大坪医院儿科 重庆,400042
- 2. 第三军医大学西南医院儿科 重庆,400038
- 3. 第三军医大学新桥医院儿科 重庆,400037
- 4. 重庆医科大学附属第一医院妇产科 重庆,400014
- 折叠
摘要
Abstract
Objective To evaluate maternal and pediatric outcome after maternal cancer diagnosed during pregnancy.Methods This was a prospective,multi-center cohort study conducted in the 3 affiliated hospital of Third Military Medical University.Inclusion criteria were women pathologically diagnosed with cancer during pregnancy (case group),each control children must meet the same conditions and were matched in a 1:1 ratio (control group).Maternal and pediatric informations of two groups were collected,in order to investigate the clinical characteristics and maternal and child outcome,as well as the factors of chemotherapy intervention in case group on mortality and the Ages and Stages Questionnaires-3 (ASQ Ⅲ) of survival children.Results A total of 80,524 pregnant women from 2012 to 2016 were screened,Of whom 83(1.03‰) were diagnosed with cancerduring pregnancy.The morbidity rate of women with cancer was 0.45‰ in 2012 and 1.28‰ in 2016 increased year by year.Death occurred in 42.2％ (35/83) women during follow up to September 2017.The top 4 cancers were leukemia 26 cases,thyroid carcinoma 10 cases,cervical carcinoma 10 cases,and oophoroma cancer 8 cases.During pregnancy,24 women terminated pregnancy before 28 weeks and among them 8(33.3％) died on average (37.0±20.0)months after the diagnosis of cancer.59women continued pregnancy were included and 59 neonates were matched in a 1:1 ratio as controls.Death occurred in 47.4％ (27/59),and 10 women received chemotherapy during the second and third trimesters.There was 1 case (10％) died and no chemotherapy-associated neonatal malformations.Death occurred in 53.1％ (26/49) women without chemotherapy.Women who received chemotherapy had a statistically significant lower mortality rate when compared to the non-treatment group (P =0.336).However,The ASQ Ⅲ assessment was not different between case group and control group as well as chemotherapy subgroup and non-chemotherapy subgroup.Conclusion Chemotherapy can reduce the mortality of women diagnosed with cancer duringpregnancy,without affecting the mortality of children and ASQ Ⅲ-associated development.关键词
妊娠期/恶性肿瘤/新生儿/年龄与发育进程问卷/化疗Key words
Pregnancy/Cancer/Neonates/The Ages and Stages Questionnaires/Chemotherapy引用本文复制引用
段娟,陈龙,范悦玲,蒙萌,李婕,史源..妊娠期恶性肿瘤孕产妇和新生儿结局的前瞻性队列研究[J].中国循证儿科杂志,2017,12(5):328-332,5.
