中国药科大学学报2017，Vol.48Issue(5)：515-522,8.DOI:10.11665/j.issn.1000-5048.20170502
靶向HIF-1α/p300蛋白-蛋白相互作用抑制剂的研究进展
Advances in the HIF-1α/p300 protein-protein interaction inhibitors
摘要
Abstract
Hypoxia induced factor-1 α (HIF-1α) is a key regulation factor that helps tumor adapt itself to the hypoxia microenvironment.It regulates the expression of more than 100 target genes that control cell proliferation and survival,metabolism,angiogenesis,invasion and metastasis.HIF-1α/p300,a core complex that regulates downstream genes expression,is considered as a potential antitumor target.This review summarizes HIF-1 α signal pathway,the binding mode of HIF-1α/p300 protein-protein interaction and recent development on the HIF-1α/ p300 protein-protein interaction inhibitors,which provides reference to the design of this kind of inhibitors.关键词
缺氧诱导因子-1α/p300/蛋白-蛋白相互作用/抗肿瘤/进展Key words
HIF-1α/p300/protein-protein interaction/antitumor/progress分类
医药卫生引用本文复制引用
莫小飞,徐晓莉,王亚楼,尤启冬..靶向HIF-1α/p300蛋白-蛋白相互作用抑制剂的研究进展[J].中国药科大学学报,2017,48(5):515-522,8.基金项目
国家自然科学基金资助项目(NO.81502990,No.81573346) （NO.81502990,No.81573346）
江苏省自然科学基金资助项目(No.BK20150691)This study was supported by the National Natural Science Foundation of China (No.81502990,No.81573346) and the Natural Science Foundation of Jiangsu Province (No.BK20150691) （No.BK20150691）
