中国药科大学学报2017，Vol.48Issue(5)：523-528,6.DOI:10.11665/j.issn.1000-5048.20170503
PI3K抑制剂与其他药物联用克服耐药性的研究进展
Advances of phosphoinositide-3 kinase inhibitors in combination with other drugs to overcome drug resistance
摘要
Abstract
Phosphoinositide 3-kindase,an important signal transduction molecule in cells,plays a key role in the process of cell survival,proliferation and differentiation.Significant progress has been made in the treatment of cancer with PI3K inhibitors,yet the drug resistance of PI3K inhibitors affects their long-term efficacy in clinical treatment.In order to overcome the drug resistance,a variety of rational combined therapies have been developed.In this paper,the research progress of phosphoinositide-3 kinase inhibitors in combination with other drugs to overcome the drug resistance were reviewed.关键词
磷脂酰肌醇3-激酶/PI3K抑制剂/抗肿瘤/药物联用/耐药性Key words
phosphatidylinositol-3-kinase/PI3K inhibitors/antitumor/drug combination/resistance分类
医药卫生引用本文复制引用
贾成舒,王均伟,李慧,朱启华,葛亦然,徐云根..PI3K抑制剂与其他药物联用克服耐药性的研究进展[J].中国药科大学学报,2017,48(5):523-528,6.基金项目
国家自然科学基金资助项目(No.81502928) （No.81502928）
江苏高等学校优秀科技创新团队资助项目(2015)This study was supported by the National Natural Science Foundation of China (No.81502928) and the Program of Outstanding Scientific and Technological Innovation Team of Jiangsu Province of China in 2015 （2015）
