中国药房2017，Vol.28Issue(35)：4918-4921,4.DOI:10.6039/j.issn.1001-0408.2017.35.06
某院门诊奥美拉唑超说明书用药情况调查分析
Investigation and Analysis of Off-label Use of Omeprazole in Outpatient Department of a Hospital
摘要
Abstract
OBJECTIVE:To investigate the omeprazole off-label use and provide reference for rational drug use in clinic. METHODS:In retrospective survey,1838 omeprazole prescriptions were selected from outpatient department during Jun. 2014 to May 2017 by random number table. According to the latest drug instruction,whether the off-label use or not was determined. Off-label use was determined by reviewing domestic and foreign guidelines,literatures and Micromedex database. RESULTS:Among 1838 pre-scriptions,there were 1750 prescriptions of off-label drug use (95.21％),involving 13 items and 3 types of off-label drug use. Main type of off-label drug use was over-indication medication,involving 1747 prescriptions (96.47％). There was no statistical significance in the incidence of off-label drug use between digestive department and non-digestive department or among physicians at different levels(P>0.05). Among 13 items of off-label drug use,7 items were supported by evidence-based medicine evidence of domestic and foreign guideline,expert consensus/suggestion or literature reports,etc.;among which 1 item of off-label drug use were included in Micromedex grading system and other 6 items had no evidence-based medicine evidence. CONCLUSIONS:The phenomenon of omeprazole off-label use is widespread in outpatient department of the hospital,and some off-label drug use are sup-ported by evidences. There are differences in the quality of those evidences. It is suggested to standardize the off-label drug use to avoid legal risks and guarantee the safety of drug use for patients.关键词
门诊/奥美拉唑/超说明书用药/分析Key words
Outpatient department/Omeprazole/Off-label drug use/Analysis分类
医药卫生引用本文复制引用
蒋炜,吴晓玲,周敏华,谢奕丹,王艳,黄光鸿..某院门诊奥美拉唑超说明书用药情况调查分析[J].中国药房,2017,28(35):4918-4921,4.基金项目
广东省医院药学研究基金项目(No.2016A22) （No.2016A22）
