中国药房2017，Vol.28Issue(35)：4940-4942,3.DOI:10.6039/j.issn.1001-0408.2017.35.12
补肺化瘀汤联合化疗治疗非小细胞肺癌的临床观察
Clinical Observation of Bufei Huayu Decoction Combined with Chemotherapy in the Treatment of Non-small Cell Lung Cancer
摘要
Abstract
OBJECTIVE:To observe clinical efficacy and safety of Bufeihuayu decoction combined with chemotherapy in the treatment of non-small cell lung cancer(NSCLC)and its effects on vascular endothelial growth factor(VEGF)and immune func-tion. METHODS:A total of 120 NSCLC patients in our hospital during Oct. 2013 to Jun. 2015 selected as research object were di-vided into observation group and control group according to random number table,with 60 cases in each group. Control group was given GP(gemcitabine combined with cisplatin)chemotherapy. Observation group was additionally given Bufei huayu decoction, one dose a day,decocted to 400 mL,morning and night,on the basis of control group. Clinical efficacies of 2 groups were com-pared,and VEGF-A,VEGF-B,VEGF-C and immune indexes (CD3+,CD4+,CD8+,CD4+/CD8+) levels were compared before and after treatment. The occurrence of toxic reaction was recorded. RESULTS:Response rate and disease control rate of observa-tion group were 58.33％ and 85.00％,significantly higher than 40.00％ and 68.33％ of control group,with statistical significance (P<0.05). Before treatment,there was no statistical significance in levels of VEGF or immune indexes between 2 groups (P>0.05). After treatment,VEGF of 2 groups were decreased significantly,and observation group was significantly lower than the con-trol group,with statistical significance(P<0.05);CD4+and CD4+/CD8+of 2 groups were decreased significantly,while CD8+was increased significantly,with statistical significance(P<0.05);CD4+ and CD4+/CD8+ of observation group were significantly higher than those of control group,while CD8+ was decreased significantly;CD3+ of control group was decreased significantly and lower than observation group,with statistical significance (P<0.05). The incidence of leucopenia,thrombocytopenia,decrease of hemo-globin,elevation of transaminase,increase of bilirubin and digestive tract reaction in observation group was significantly lower than control group,with statistical significance(P<0.05). CONCLUSIONS:Bufei huayu decoction combined with chemotherapy shows significant therapeutic efficacy for NSCLC,can effectively inhibit VEGF,improve immune function and relieve toxic reaction.关键词
补肺化瘀汤/非小细胞肺癌/血管内皮因子/免疫功能Key words
Bufei huayu decoction/Non-small-cell lung cancer/Vascular endothelial growth factor/Immune function分类
医药卫生引用本文复制引用
冯原,周继红,陈斯宁,江颖,周颖..补肺化瘀汤联合化疗治疗非小细胞肺癌的临床观察[J].中国药房,2017,28(35):4940-4942,3.基金项目
广西中医药民族医药传承创新专项课题(No.GZLC14-23) （No.GZLC14-23）
广西医疗卫生适宜技术开发与推广应用项目(No.S2017056) （No.S2017056）
