中国药房2017，Vol.28Issue(35)：4952-4955,4.DOI:10.6039/j.issn.1001-0408.2017.35.15
PCI术前给予替罗非班联合阿托伐他汀对急性心肌梗死患者外周血微RNA表达及血管内皮功能的影响
Effects of Tirofiban Combined with Atorvastatin before PCI on miRNA Expression of Peripheral Blood and Vascular Endothelial Function in Acute Myocardial Infarction Patients
摘要
Abstract
OBJECTIVE:To investigate the effects of tirofiban combined with atorvastation before PCI on the miRNA expres-sion of peripheral blood and vascular endothelial function in acute myocardial infarction(AMI)patients. METHODS:A total of 80 patients with AMI selected from our hospital as reaserch objects during Jan. 2015-Jun. 2016 were divided into control group and ob-servation group according to random number table,with 40 cases in each group. Both groups received anticoagulant therapy. Con-trol group was given Aspirin enteric-coated tablets 300 mg+Clopidogrel sulfate tablets 75 mg+ Atorvastatin calcium tablets 20 mg orally 30 min before PCI. Observation group was additionally given Tirofiban hydrochloride for injection with initial dose of 0.5 mg+0.9％ Sodium chloride injection 100 mL,iv,then adjusted to pump injection of 0.4 μg/(kg·min),30 min later adjusted to pump injection of 0.1 μg/(kg·min),for consecutive 24 h. The levels of peripheral miRNA (miRNA-1,miRNA-133a,miR-NA-208b,miRNA-499),the levels of brachial artery diameter and vascular endothelial function indexes(vWF,ET-1,NO)were observed in 2 groups before medication and after PCI,and the occurrence of ADR was recorded. RESULTS:Before treatment, there was no statistical significance in above indexes between 2 groups(P>0.05). After treatment,miRNA expression,the levels of vWF and ET-1 were decreased significantly in 2 groups,and observation group was significantly lower than control group,with statistical significance (P<0.05). The brachial artery diameter and NO levels of 2 groups were increased significantly,and observation group was significantly greater or higher than con-trol group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups during treatment. CONCLU-SIONS:For AMI,tirofiban combined with atorvastation before PCI can reduce miRNA expression,increase brachial artery diame-ter and protect vascular endothelial function with good safety.关键词
替罗非班/阿托伐他汀/急性心肌梗死/经皮冠状动脉介入术/外周血/微RNA/血管内皮功能Key words
Tirofiban/Atorvastatin/Acute myocardial infarction/PCI/Peripheral blood/miRNA/Vascular endothelial function分类
医药卫生引用本文复制引用
张建坤,单微,张迎春,贾翠英,于磊,耿峰,李春峰..PCI术前给予替罗非班联合阿托伐他汀对急性心肌梗死患者外周血微RNA表达及血管内皮功能的影响[J].中国药房,2017,28(35):4952-4955,4.基金项目
黑龙江省卫生计生委科研课题(No.2014-185) （No.2014-185）
