中国药理学通报2018，Vol.34Issue(1)：1-4,4.DOI:10.3969/j.issn.1001-1978.2018.01.001
NMDA受体相关抗抑郁药物的研究进展
Advances in NMDA receptors-related antidepressants
摘要
Abstract
Recent studies have demonstrated that ketamine , an N-methyl-D-aspartate ( NMDA ) receptor antagonist , can pro-duce rapid and effective antidepressant actions , especially for patients with treatment-resistant depression , bipolar disorder and suicide idea.However, the clinical application of ketamine is limited by its psychotomimetic adverse reactions and potential a-buse.Therefore, development of novel ketamine-like antidepres-sant agents with fewer side effects is actively investigated currently.The latest researches indicate that the metabolites of ket-amine, the S-ketamine/R-ketamine and the modulators of NM-DA receptor subunits can exert safe and effective antidepressant actions.In this article, the research advance in NMDA recep-tors-related antidepressants mentioned above will be reviewed .关键词
NMDA受体/氯胺酮/代谢产物/同分异构体/亚型/抗抑郁药Key words
N-methyl-D-aspartate receptor/ketamine/metabo-lites/isomeride/isoforms/antidepressant分类
医药卫生引用本文复制引用
张广芬,杨建军..NMDA受体相关抗抑郁药物的研究进展[J].中国药理学通报,2018,34(1):1-4,4.基金项目
国家自然科学基金资助项目(No81471105,81503053) （No81471105,81503053）
