中国药理学通报2018，Vol.34Issue(1)：5-8,4.DOI:10.3969/j.issn.1001-1978.2018.01.002
基于TGF-β1/Smads信号通路治疗心肌梗死后心肌纤维化的研究进展
The research progress on treatment of myocardial fibrosis by regulating TGF-β1/Smads pathway
摘要
Abstract
Myocardial fibrosis leads to cardiac remodeling and heart failure after myocardial infarction .The mechanism of ven-tricular remodeling after myocardial infarction is complicated , which results from multi-factor interactions .TGF-β1-dependent Smads signal pathway is a definite mechanism which plays an important role in the process of myocardial fibrosis .Myocardial infarction activates the TGF-β1, which links the downstream Smads signaling to play a sustained biological effects via the ac-cumulation of activated cardiac fibroblasts and excess deposition of extracellular matrix , and the differentiation from myocardial fibroblasts to myofibroblasts .Therefore, how to block or control TGF-β1/Smads signaling pathway is an important research di-rection for the treatment of myocardial fibrosis after myocardial infarction.This paper reviews the current studies of the treat-ment of myocardial fibrosis after myocardial infarction based on the TGF-β1/Smads signaling pathway .关键词
心肌梗死/心肌纤维化/TGF-β/Smads/TGF-β1/治疗靶点/治疗进展Key words
myocardial infarction/myocardial fibrosis/TGF-β/Smads/TGF-β1/Smad2/3/therapeutic target/therapeutic pro-gress分类
医药卫生引用本文复制引用
石斌豪,徐宗佩,樊官伟..基于TGF-β1/Smads信号通路治疗心肌梗死后心肌纤维化的研究进展[J].中国药理学通报,2018,34(1):5-8,4.基金项目
国家中医临床研究基地业务建设科研专项课题 (NoJDZX2015006) （NoJDZX2015006）
