中国药理学通报2018，Vol.34Issue(1)：12-15,4.DOI:10.3969/j.issn.1001-1978.2018.01.004
酸敏感离子通道1a在自身免疫性疾病发病机制中的研究进展
Role of acid-sensing ion channel 1a in pathogenesis of autoimmune diseases
摘要
Abstract
Acid-sensing ion channels ( ASICs) are proton-gated channels expressed widely in the central nervous systems and pe-ripheral tissues, among which ASIC1a is a core part and plays an important role in many physiological and pathological proces-ses.As a key receptor for extracellular protons , ASIC1a is in-volved in a variety of pathophysiological processes involving tis-sue acidosis, such as pain, inflammation, seizures and multiple sclerosis.Autoimmune disease is a chronic inflammatory dis-ease , and the excessive activation of T , B cells leads to multiple tissue and organ damage when the body responds to autoantigen immune response . In recent years , studies have found that ASIC1a plays an important role in the development of various au-toimmune diseases.In this paper, the biological characteristics of ASIC1a are briefly reviewed , and the research progress of ASIC1a in the development and progression of autoimmune dis-eases is discussed .关键词
酸敏感离子通道1a/自身免疫性疾病/酸中毒/炎症/机制/靶点Key words
acid-sensing ion channel 1a/autoimmune disea-ses/acidosis/inflammation/mechanism/target分类
医药卫生引用本文复制引用
陈勇,葛金芳,陈飞虎..酸敏感离子通道1a在自身免疫性疾病发病机制中的研究进展[J].中国药理学通报,2018,34(1):12-15,4.基金项目
国家自然科学基金资助项目(No81271949,81672127) （No81271949,81672127）
