中国药理学通报2018，Vol.34Issue(1)：16-19,4.DOI:10.3969/j.issn.1001-1978.2018.01.005
TXNIP介导的氧化应激在疾病中的作用机制
Action and mechanism of oxidative stress mediated by TXNIP in diseases
摘要
Abstract
Thioredoxin-interacting protein ( TXNIP) suppresses the antioxidative function of thioredoxin ( Trx ) by combining with thioredoxin ( Trx).Therefore, it promotes the generation and accumulation of reactive oxygen species ( ROS ) , inducing endoplasmic reticulum stress and mitochondrial stress , which leads to cellular inflammation or cellular apoptosis ultimately . TXNIP-mediated oxidative stress plays a crucial role in control-ling the generation and development of some diseases , such as diabetes and its complications ( diabetic nephropathy diabetic retinopathy etc .) , atherosclerosis ischemia/reperfusion injury , cancers ( hepatocellular carcinoma , carcinoma of urinary blad-der, mammary cancer , leukemia ) etc.Here, we try to review the action and mechanism of oxidative stress mediated by TXNIP in the diseases and the progress in research .关键词
硫氧还蛋白相互作用蛋白(TXNIP)/氧化应激/线粒体应激/内质网应激/细胞炎症/细胞凋亡Key words
thioredoxin-interacting protein ( TXNIP)/oxidative stress/mitochondrial stress/endoplasmic reticulum stress/cel-lular inflammation/cellular apoptosis分类
医药卫生引用本文复制引用
莫与琳,杨亚军,崔燎..TXNIP介导的氧化应激在疾病中的作用机制[J].中国药理学通报,2018,34(1):16-19,4.基金项目
国家自然科学基金资助项目(No81673814) （No81673814）
广东省科技计划项目(No2016A020215148) （No2016A020215148）
广东省医学科研基金(NoA2016293) （NoA2016293）
