中国药理学通报2018，Vol.34Issue(1)：19-22,4.DOI:10.3969/j.issn.1001-1978.2018.01.006
中药活性成分降尿酸作用机制研究进展
Research advances in mechanism of active components of traditional Chinese medicine for reducing uric acid
摘要
Abstract
Hyperuricemia is a heterogeneous group of diseases caused by disorders of purine metabolism and /or excretion of uric acid reduction .Chinese medicine treatment of hyperurice-mia has gradually attracted attention , and made significant pro-gress.In recent years a large number of experimental studies have shown that flavonoids , saponins , alkaloids and other active components of traditional Chinese medicine can reduce uric acid by inhibiting the activity of key enzymes in purine metabolism ,or by increasing the excretion of uric acid through regulating the expression of uric acid transporters , thereby playing an important role in reducing uric acid .Based on the pathogenesis of hyperu-ricemia, the mechanism of active components of traditional Chi-nese medicine for reducing uric acid is summarized , and recent research reports are reviewed .关键词
中药/黄酮/皂苷/生物碱/高尿酸血症/黄嘌呤氧化酶/尿酸转运蛋白Key words
traditional Chinese medicine/flavonoid/saponin/alkaloid/hyperuricemia/xanthine oxidase/urate transporter分类
医药卫生引用本文复制引用
周洁,孙超,李飞..中药活性成分降尿酸作用机制研究进展[J].中国药理学通报,2018,34(1):19-22,4.基金项目
国家自然科学基金资助项目(No81402994) （No81402994）
湖北省自然科学基金资助项目(No2014CFB652) （No2014CFB652）
湖北省"2011 计划"开放基金创新团队项目(No2011JH-2014CXTT08) （No2011JH-2014CXTT08）
湖北省药用植物综合利用工程技术研究中心项目 (NoGC2015202) （NoGC2015202）
湖北医药学院博 士 启动 金项 目 (No2014QDJZR03) （No2014QDJZR03）
