中国医学科学院学报2017，Vol.39Issue(5)：699-704,6.DOI:10.3881/j.issn.1000-503X.2017.05.017
下丘脑-垂体-肾上腺轴和下丘脑-垂体-卵巢轴在多囊卵巢综合征神经内分泌功能紊乱中的作用
Roles of Hypothalamic-Pituitary-Adrenal Axis and Hypothalamus-Pituitary-Ovary Axis in the Abnormal Endocrine Functions in Patients with Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of childbearing age.While it can be affected by a variety of factors,its pathophysiology remains unclear.Its clinical features mainly include anovulation,hyperandrogenism,and hyperinsulinemia,which are closely related with abnormal neuroendocrine system.Hypothalamic-pituitary-gonadal axis (HPG) plays a crucial regulatory role in various life activities in mammals.In particular,hypothalamic-pituitary-adrenal (HPA) axis and hypothalamus-pituitary-ovary (HPO) axis can be abnormal in PCOS patients.The corresponding abnormalities include abnormal gonadotropin releasing hormone pulse frequency,increased luteinizing hormone/follicle-stimulating hormone ratio,and excessive excretion of adrenal and ovarian androgens.Meanwhile,insulin and leptin also play key roles in endocrine dysfunction in PCOS patients.This article systematically reviews the role of HPA axis and HPO axis in the neuroendocrine dysfunction in PCOS patients.关键词
多囊卵巢综合征/下丘脑-垂体-肾上腺轴/下丘脑-垂体-卵巢轴/内分泌功能Key words
polycystic ovary syndrome/hypothalamic-pituitary-adrenal axis/hypothalamus-pituitary-ovary axis/endocrine functions分类
医药卫生引用本文复制引用
王凡,张正红,肖开转,王正朝..下丘脑-垂体-肾上腺轴和下丘脑-垂体-卵巢轴在多囊卵巢综合征神经内分泌功能紊乱中的作用[J].中国医学科学院学报,2017,39(5):699-704,6.基金项目
国家自然科学基金(31271255)、福建省自然科学基金(2016J01145)和福建省教育厅科技项目(JAT160118) Supported by the National Natural Sciences Foundation of China (31271255),the Natural Science Foundation of Fujian Provine (2016J01145),and the Science and Technology Project of Education Department of Fujian Province (JAT160118) （31271255）
