中国中西医结合杂志2017，Vol.37Issue(12)：1435-1438,4.DOI:10.7661/j.cjim.20170828.250
补肾中药联合避孕药预治疗肾虚型卵巢低反应临床观察
Treatment of Poor Ovarian Response Patients with Shen Deficiency Syndrome by Chinese Drugs for Invigorating Shen Combined Compound Oral Contraceptives
摘要
Abstract
Objective To study clinical effect of Chinese drugs for invigorating Shen (CDIS) combined compound oral contraceptives (COC) in treatment of poor ovarian response (POR) patients with Shen deficiency syndrome (SDS) undergoing in vitro fertilization-embryo transfer (IVF-ET).Methods Totally 180 IVF-ET POR patients were assigned to the combined treatment group,the COC treatment group,and the control group by random number table,60 cases in each group.All patients were treated with gonadotropin-releasing hormone agonist (GnRHa) short protocol IVF-ET treatment.Patients in the combined treatment group took CDIS combined COC from the IVF-ET superovulation cycle of the last menstrual cycle.Patients in the COC treatment group took COC at the same period.Those in the control group took equal dose of placebos.The improvement of SDS was observed in the three groups before and after treatment.The estradiol (E2) level on theday of human chorionic gonadotropin (HCG),gonadotropin (Gn) dosage,the number of days using Gn,the number of retrieved oocytes,the fertilization rate,rate of available embryos,high quality embryo rate,and clinical pregnancy rate were also observed and calculated.Results Compared with the control group,Gn dosage and the number of days using Gn were significantly reduced,the level of E2 on the day of HCG,the number of retrieved oocytes,the fertilization rate,and the available embryo rate were significantly higher in the combined treatment group (P ＜0.05,P ＜0.01).SDS scores were significantly lower (P ＜0.01).Compared with before treatment,symptoms of SDS were significantly improved in the combined treatment group (P ＜0.01).Compared with the control group,the number of retrieved oocytes increased in the COC treatment group (P ＜ 0.01).Compared with the COC treatment group,Gn dosage and the number of days using Gn were significantly reduced;the level of E2 on the day of HCG,the number of retrieved oocytes and the fertilization rate were significantly higher;SDS scores were significantly lower (P ＜ 0.01) in the combined treatment group (P ＜ 0.01).Conclusion CDIS combined with COC could increase the number of retrieved oocytes and E2 level on the day of HCG,reduce the Gn dosage and the number of days using Gn,elevate the fertilization rate and the rate of available embryos,and improve the symptoms of SDS in POR patients undergoing IVF-ET.关键词
补肾中药/避孕药/卵巢低反应Key words
Chinese drugs for invigorating Shen/contraceptives/poor ovarian response引用本文复制引用
连方,李冉..补肾中药联合避孕药预治疗肾虚型卵巢低反应临床观察[J].中国中西医结合杂志,2017,37(12):1435-1438,4.基金项目
国家自然科学基金资助项目(No.81273790,No.81473720) （No.81273790,No.81473720）
山东省研究生教育创新计划项目(No.sdyc11099) （No.sdyc11099）
