摘要
Abstract
Objective To study the application of Kuntai Capsule (KTC) in poor ovarian response (POR) patients undergoing in vitro fertilization-embryo transfer (IVF-ET).Methods Recruited were 90 diminished ovarian reserve (DOR) infertility patients at Department of Reproductive Medicine,Weifang People's Hospital from April 2015 to April 2016.All patients received routine micro-stimulation protocol and signed informed consent.They were assigned to the observation group (48 cases) and the control group (42 cases) according to whether they would accept treatment protocols.Patients in the observation group took KTC one month earlier before they entered the menstrual cycle,while those in the control group entered the menstrual cycle directly.Age,duration of infertility,body mass index (BMI),scores for Shen yin deficiency syndrome (SYDS),levels of basal follicle stimulating hormone (bFSH) basal luteinizing hormone (bLH),basal estradiol (bE2),and antral follicle count (AFC),anti-Müllerian hormone (AMH) were observed in the two groups.Gonadotropin (Gn) using days,Gn dosage,E2 level in single mature follicle (diameter ≥14 mm) on human chorionic gonadotrophin (HCG) day,the number of oocytes retrieved,portable embryos number,and high quality embryos number were compared during IVF.Results No statistical difference was shown in Gn using days or Gn dosage between the two groups (P ＞0.05).E2 levels in single mature follicle on HCG day,number of oocytes retrieved,and portable embryos number were higher in the observation group than in the control group (P ＜0.05).The high quality embryos number showed increasing tendency,but with no statistical difference between the two grups (P ＞0.05).Conclusion KTC could improve E2 levels in single mature follicle on HCG day,increase number of oocytes retrieved and portable embryos number in POR patients undergoing IVF-ET,thus improving the outcome of IVF.关键词
坤泰胶囊/卵巢储备功能减退/卵巢低反应/体外受精-胚胎移植Key words
Kuntai Capsule/diminished ovarian reserve/poor ovarian response/in vitro fertilization-embryo transfer
