组织工程与重建外科杂志2017，Vol.13Issue(6)：313-317,5.DOI:10.3969/j.issn.1673-0364.2017.06.003
脐带间充质干细胞鞘内注射治疗脊髓损伤的长期临床观察
Long-Term Clinical O bservation of Umbilical Cord Mesenchymal Stem Cells in Treating Spinal Cord Injury by Intrathecal Injection
摘要
Abstract
Objective To observe the clinical efficacy and safety of umbilical cord mesenchymal stem cells (UC-MSCs) in treating spinal cord injury (SCI) by intrathecal injection. Methods From January 2008 to October 2013, 35 admitted patients with SCI were given UC-MSCs by intrathecal injection for 46 courses, at a dose of 1×106 cells/kg body weight once a week, 4 times as a course. American Spinal Injury Association (ASIA) standard and International Association of Neurorestoratology SCI Functional Rating Scale (IANR-SCIFRS) were used to evaluate SCI patient's neural function and ability of daily living. Results Among 35 cases, 22 cases were effective. Compared with the scale before therapy, effective patients'algaesthesis, tactile sensation, motion, activity of daily living scale were obviously increased one month after therapy (P<0.01). Nine effective patients received 2 to 3 courses of treatment, the effects of 7 cases were further enhanced. The effective rate of 25 cases with incomplete SCI was 88.46%, whereas all of 10 cases with complete SCI had no response. After therapy, there were headache, lumbago or fever in individual patients and disappeared within 1-3 days. All patients were followed up for 45 months to 114 months (average 84 months), no treatment-related adverse events happened. The effect was stable in effective patients. Conclusion UC-MSCs therapy by intrathecal injection is safe, and can ameliorate most of incomplete SCI patient's neurological function, multiple courses of treatment is likely to further improve the efficacy of patients.关键词
脐带间充质干细胞/脊髓损伤/鞘内注射Key words
Umbilical cord mesenchymal stem cells/Spinal cord injury/Intrathecal injection分类
医药卫生引用本文复制引用
刘静,韩冬梅,薛梅,阎洪敏,董磊,朱玲,郭子宽,王恒湘..脐带间充质干细胞鞘内注射治疗脊髓损伤的长期临床观察[J].组织工程与重建外科杂志,2017,13(6):313-317,5.基金项目
首都发展基金项目(2007-2033) （2007-2033）
国家高新技术研究发展计划 (863 项目,2007AA022454) （863 项目,2007AA022454）
国家重大新药创制基金(20092x09503-019) （20092x09503-019）
军队临床高新技术重大项目(2010gxjs049). （2010gxjs049）
