动物营养学报2017，Vol.29Issue(12)：4287-4294,8.DOI:10.3969/j.issn.1006-267x.2017.12.007
一磷酸腺苷激活的蛋白激酶对动物糖脂代谢的调节作用
Regulatory Effects of Adenosine Monophosphate-Activated Protein Kinase on Glucose and Lipid Metabolism in Animals
摘要
Abstract
The adenosine monophosphate-activated protein kinase ( AMPK ) is found in all eukaryotic cells. AMPK activity is a response to adenosine monophosphate ( AMP)/adenosine triphosphate ( ATP) .When a stress causes an inhibition of ATP production or an increase of ATP consumption, cellular AMP/ATP increa-ses, AMPK is activated.Once activated AMPK can phosphorylates its downstream target proteins.As a result, the lipid and carbohydrate metabolisms are changed towards the switches on promoting ATP-producing and in-hibiting ATP-consumption pathways, such as inhibitions of fatty acid and glycogen synthesis, stimulations of fatty acid oxidation and glucose absorption, by which energy in cells are rapidly recovered.Thus AMPK is called regulator of cell energy, and plays an important role for animals to adapt to the environment.This review summarized the structure, distribution, activity regulation and the regulatory roles on the glucose and lipid me-tabolism of AMPK based on the previous studies at home and abroad.关键词
一磷酸腺苷激活的蛋白激酶/动物/糖代谢/脂代谢Key words
AMPK/animal/glucose metabolism/lipid metabolism分类
农业科技引用本文复制引用
高晓娜,郭小权..一磷酸腺苷激活的蛋白激酶对动物糖脂代谢的调节作用[J].动物营养学报,2017,29(12):4287-4294,8.基金项目
国家自然科学基金(31460679) （31460679）
江西省自然科学基金重点项目(2017ACB20012) （2017ACB20012）
