分析化学2017，Vol.45Issue(12)：1786-1794,9.DOI:10.11895/j.issn.0253-3820.171324
电感耦合等离子体质谱用于多组分免疫分析研究进展
Development of Multiplex Immunoassay Based on Inductively Coupled Plasma Mass Spectrometry
摘要
Abstract
Immunoassay is of great importance in the field of clinical detection. Our group proposes the inductively coupled plasma mass spectrometry ( ICP-MS) based immunoassay. Multiplex immunoassay can be realized by stable isotope tagging strategy combined with ICP-MS detection. Since then, large amount of researches in this field have been made at home and abroad, and the method has been proved applicable to the analysis of biological small molecules, proteins, nucleic acids and cells. In this article, the history and development of immunoassay, the characters of ICP-MS based immunoassay, single component and multiplex immunoassay, and the magnetic immunoassay that is recently fast developed are reviewed. The prospect of the developing tendency is also anticipated, hoping to provide references for the research in this field.关键词
免疫分析/电感耦合等离子体质谱/多组分分析/评述Key words
Immunoassay/Inductively coupled plasma mass spectrometry/Multiplex immunoassay/Review引用本文复制引用
孙公伟,洪伟哲,张钰清,胡志安,邢志,张四纯,张新荣..电感耦合等离子体质谱用于多组分免疫分析研究进展[J].分析化学,2017,45(12):1786-1794,9.基金项目
本文系国家自然科学基金项目(Nos.21390410, 21621003)资助 This work was supported by the National Natural Science Foundation of China (Nos.21390410, 21621003). （Nos.21390410, 21621003）
