法医学杂志2017，Vol.33Issue(5)：493-496,4.DOI:10.3969/j.issn.1004-5619.2017.05.009
缺血修饰白蛋白在急性缺血性心脏病中的法医学应用
Application of Ischemia Modified Albumin for Acute Ischemic Heart Disease in Forensic Science
摘要
Abstract
Objective To explore the application value and forensic significance of ischemia modified albumin (IMA) in pericardial fluid to diagnose sudden cardiac death.Methods IMA level in pericardial fluid was detected in acute ischemic heart disease group (n=36),acute myocardial infarction group (n=6),cardiomyopathy group (n=4) and control group (n=15) by albumin cobalt binding method.The levels of IMA were compared among these groups.The best cut-off IMA value was estimated and the sensitivity and specificity of acute myocardial ischemia group was distinguished from control group by receiver operating characteristics (ROC) curve.Results The IMA level in acute ischemic heart disease group was significantly higher than that of control group (P＜0.05).Compared with acute myocardial infarction group and cardiomyopathy group,the IMA level in acute ischemic heart disease group had no significant difference (P＜0.05).The cut-off value for the identification of acute myocardial ischemia which obtained by ROC analysis was 40.65U/mL.And the sensitivity and specificity for distinguishing acute ischemia cardiac disease was 60.0％ and 80.5％,respectively.Conclusion The IMA value in pericardial fluid can be a reference marker for the diagnosis of acute myocardial ischemia,which also can provide objective basis for the forensic identification of sudden cardiac death.关键词
法医病理学/猝死,心脏/心肌缺血/白蛋白类Key words
forensic pathology/death, sudden, cardiac/myocardial ischemia/albumins分类
社会科学引用本文复制引用
王鹏,朱泽磊,朱宁,于浩,岳强,王晓龙,冯春梅,王昌亮,张国华..缺血修饰白蛋白在急性缺血性心脏病中的法医学应用[J].法医学杂志,2017,33(5):493-496,4.基金项目
公安部应用创新计划资助项目(2009YYCXLNST021) （2009YYCXLNST021）
