海南医学院学报2017，Vol.23Issue(18)：2472-2475,4.DOI:10.13210/j.cnki.jhmu.20170919.001
左卡尼汀+辅酶Q10辅助治疗对慢性心力衰竭患者血管活性分子、内皮损伤、氧化应激反应的影响
Effect of levocarnitine + coenzyme Q10 adjuvant therapy on vasoactive molecules, endothelial injury and oxidative stress in patients with chronic heart failure
摘要
Abstract
Objective:To study the effect of levocarnitine + coenzyme Q10 adjuvant therapy on vasoactive molecules,endothelial injury and oxidative stress in patients with chronic heart failure.Methods:90 patients with chronic heart failure who were treated in the hospital between December 2014 and December 2016 were collected and divided into control group and observation group by random number table method,45 cases in each group.Control group received conventional therapy,and observation group received levocarnitine + coenzyme Q10 adjuvant therapy on the basis of conventional therapy.The differences in vasoactive molecule,endothelial injury and oxidative stress levels were compared between the two groups before and after treatment.Results:Before treatment,the differences in vasoactive molecule,endothelial injury and oxidative stress levels were not statistically significant between the two groups of patients.After treatment,serum vasoactive molecules ET-1,Ang Ⅱ and TXB2 contents of observation group were lower than those of control group while NO content was higher than that of control group;endothelial function indexes FMD level was higher than that of control group;serum oxidative stress indexes SOD and T-AOC contents were higher than those of control group while MDA and ROS contents were lower than those of control group.Conclusion:Levocarnitine + coenzyme Q10 adjuvant therapy can optimize the vascular activity,and reduce the endothelial injury and systemic oxidative stress response in patients with chronic heart failure.关键词
慢性心力衰竭/左卡尼汀/辅酶Q10/内皮损伤/氧化应激Key words
Chronic heart failure/levocarnitine/coenzyme Q10/endothelial injury/oxidative stress分类
医药卫生引用本文复制引用
李勤,刘盈盈..左卡尼汀+辅酶Q10辅助治疗对慢性心力衰竭患者血管活性分子、内皮损伤、氧化应激反应的影响[J].海南医学院学报,2017,23(18):2472-2475,4.基金项目
四川省医学会课题项目(Q15035) （Q15035）
It is supported by Sichuan Medical Association Project (Q15035). （Q15035）
