海南医学院学报2017，Vol.23Issue(18)：2480-2483,4.DOI:10.13210/j.cnki.jhmu.20170920.020
非洛地平联合厄贝沙坦对青年男性原发性高血压患者血尿酸、血清脂联素及肾功能的影响
Effect of felodipine combined with irbesartan on the blood uric acid, serum adiponectin, and renal function in young males with essential hypertension
摘要
Abstract
Objective:To explore the effect of felodipine in combined with irbesartan on the blood uric acid (UA),serum adiponectin (APN),and renal function in young males with essential hypertension (EH).Methods:A total of 134 young male patients with EH who were admitted in our hospital from January,2016 to January,2017 were included in the study and randomized into the observation group and the control group.The patients in the control group were given felodipine sustanined release tablets,5 mg/time,1 time/d.On this basis,the patients in the observation group were given irbesartan,150 mg/time,1 time/d.To those whose blood pressure was not reduced under 140/90 mmHg after 4-week treatment,the dose of felodipine sustanined release tablets was increased to 10 mg/d.A maintenance dose was adopted according to the individual conditions until the ideal blood pressure reduction effect was achieved.The morning fasting venous blood was collected before treatment,4 and 12 weeks after treatment in the two groups.ELISA was used to detect APN level.Uricase-peroxide enzymic method was used to detect UA level.The full automatic biochemical analyzer was used to detect BUN and Scr.Ccr was calculated.Urine was collected.RIA was used to detect 24h Upro.The morning fasting venous blood before treatment,24and 48 weeks after treatment was collected.RIA was used to detect the serum T and SHBG levels.Results:Scr and 24h Upro 4 and 12 weeks after treatment in the two groups were gradually reduced,while Ccr was gradually elevated.BUN 12 weeks after treatment in the observation group was significantly reduced (P＜0.05).Scr and 24h Upro 4 and 12 weeks after treatment in the observation group were significantly lower than those in the control group,while Ccr was significantly higher than that in the control group (P＜0.05).BUN 12 weeks after treatment in the observation group were significantly lower than those in the control group (P ＜0.05).T level 24 and 48 weeks after treatment in the two groups was significantly elevated (P＜0.05),while SHBG after treatment was not significantly changed.T level 24 and 48 weeks after treatment in the observation group was significantly higher than that in the control group (P＜0.05).APN 4 and 12 weeks after treatment in the two groups was significantly elevated,while UA was significantly reduced (P＜0.05).APN 4 and 12 weeks after treatment in the observation group was significantly higher than that in the control group,while UA was significantly lower than that in the control group (P ＜0.05).Conclusions:Felodipine in combined with irbesartan in the treatment of EH in young males can effectively regulate APN and UA levels,protect the renal function,enhance the sex hormone levels,and has a great significance in reducing the target organ damage and improving the prognosis.关键词
非洛地平/厄贝沙坦/青年男性/原发性高血压/血尿酸/血清脂联素/肾功能Key words
Felodipine/irbesartan/young males/EH/UA/APN/renal function分类
医药卫生引用本文复制引用
王晶,刘艳丽,王雅静,刘丽静..非洛地平联合厄贝沙坦对青年男性原发性高血压患者血尿酸、血清脂联素及肾功能的影响[J].海南医学院学报,2017,23(18):2480-2483,4.基金项目
唐山市科技局指导计划项目(13130266a) （13130266a）
It is supported by Scientific and Technological Bureau Guiding Plan Project of Tangshan City (13130266a). （13130266a）
