海南医学院学报2017，Vol.23Issue(18)：2499-2502,2506,5.DOI:10.13210/j.cnki.jhmu.20170829.009
超短波电疗联合抗氧化及神经营养对糖尿病周围神经病变患者神经传导功能及血清细胞因子的影响
Effect of ultrashort wave therapy combined with antioxidant and neurotrophy therapy on nerve conduction function and serum cytokines in patients with diabetic peripheral neuropathy
摘要
Abstract
Objective:To study the effect of ultrashort wave therapy combined with antioxidant and neurotrophy therapy on nerve conduction function and serum cytokines in patients with diabetic peripheral neuropathy.Methods:A total of 128 patients who were diagnosed with DPN in South District of Guang'anmen Hospital of China Academy of Chinese Medical Sci ences between May 2014 and February 2017 were selected as the research subjects and randomly divided into electrotherapy + drug group and routine drug group;the nerve conduction velocity as well as serum levels of nerve cytokines and inflammatory cytokines were measured before treatment and 8 weeks after treatment.Results:MNCV of median nerve and common peroneal nerve,SNCV of median nerve and superficial peroneal nerve as well as serum CNTF,BDNF,SDF-1α,IGF-1,CAT and HO-1 levels in both groups 8 weeks after treatment were significantly higher than those before treatment while serum ICAM-1,TNF-α,IL-6,ET-1,MDA and 8-OHdG levels were significantly lower than those before treatment;MNCV of median nerve and common peroneal nerve,SNCV of median nerve and superficial peroneal nerve as well as serum CNTF,BDNF,SDF-1α,IGF-1,CAT and HO-1 levels in electrotherapy + drug group 8 weeks after treatment were significantly higher than those in routine drug group while serum ICAM-1,TNF-α,IL-6,ET-1,MDA and 8-OHdG levels were significantly lower than those in routine drug group.Conclusions=Ultrashort wave therapy combined with antioxidant and neurotrophy therapy for DPN can improve the nerve conduction function and neurotrophic state,and also inhibit the inflammatory response and oxidative stress response.关键词
糖尿病周围神经病变/超短波电疗/炎症反应/氧化应激Key words
Diabetic peripheral neuropathy/Ultrashort wave therapy/Inflammatory response/Oxidative stress分类
医药卫生引用本文复制引用
李乔,张博,谢冰昕..超短波电疗联合抗氧化及神经营养对糖尿病周围神经病变患者神经传导功能及血清细胞因子的影响[J].海南医学院学报,2017,23(18):2499-2502,2506,5.基金项目
中国中国中医科学院广安门医院课题(y2014-05) （y2014-05）
It is supported by Guang'anmen Hospital Project of China Academy of Chinese Medical Sciences (y2014-05). （y2014-05）
